Pediatric Rheumatology

Clinical Correlates of JIA Relapse After Biologic Therapy Discontinuation

Clinical Correlates of JIA Relapse After Biologic Therapy Discontinuation

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The investigators sought to evaluate the time patients were in remission after discontinuing biologic therapy for the treatment of JIA.

Actemra SC Approved to Treat Polyarticular Juvenile Idiopathic Arthritis

Actemra SC Approved to Treat Polyarticular Juvenile Idiopathic Arthritis

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The FDA has approved the subcutaneous formulation of Actemra for the treatment of active polyarticular juvenile idiopathic arthritis.

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

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Baseline depressive symptoms were associated with pain and disability in adolescents with juvenile idiopathic arthritis.

Efficacy, Safety of Adalimumab vs Infliximab in JIA-Associated Uveitis

Efficacy, Safety of Adalimumab vs Infliximab in JIA-Associated Uveitis

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Researchers evaluated the safety and efficacy of adalimumab and infliximab in the treatment of juvenile idiopathic arthritis-associated uveitis in patients treated for at least 2 years.

Amendment Added to OMERACT Ultrasound Definition of Healthy Pediatric Joints

Amendment Added to OMERACT Ultrasound Definition of Healthy Pediatric Joints

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Researchers sought to include Doppler findings in the evaluation and definition of normal joint features that can be visualized in healthy children in different age groups.

Treatment Targets in JIA: Comparing Definitions of Clinically Inactive Disease

Treatment Targets in JIA: Comparing Definitions of Clinically Inactive Disease

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Investigators aimed to examine the use of treatment targets in juvenile idiopathic arthritis in terms of joint limitations, functional ability, psychosocial health, and pain levels.

Managing Uveitis in Juvenile Idiopathic Arthritis: Consensus-Based Recommendations

Managing Uveitis in Juvenile Idiopathic Arthritis: Consensus-Based Recommendations

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The SHARE initiative has provided recommendations for the diagnosis and treatment of juvenile idiopathic arthritis-associated uveitis.

Clinical Features Identified in Enthesitis-Related Juvenile Idiopathic Arthritis, Juvenile Spondyloarthritis

Clinical Features Identified in Enthesitis-Related Juvenile Idiopathic Arthritis, Juvenile Spondyloarthritis

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Results confirm that juvenile spondyloarthritis is characterized by its peripheral pattern at disease onset, with peripheral arthritis and enthesitis.

Ultrasound Not Predictive of Disease Flares for Inactive Juvenile Idiopathic Arthritis

Ultrasound Not Predictive of Disease Flares for Inactive Juvenile Idiopathic Arthritis

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Abnormal ultrasound findings were common in patients with juvenile idiopathic arthritis with clinically inactive disease.

Flare Risk Examined in Juvenile Idiopathic Arthritis After Anti-TNF Therapy Discontinuation

Flare Risk Examined in Juvenile Idiopathic Arthritis After Anti-TNF Therapy Discontinuation

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Researchers sought to determine the predictors of disease flare after anti-TNF therapy discontinuation in children with polyarticular forms of juvenile idiopathic arthritis with sustained clinically inactive disease.

Examining the Role of Neutrophils in Systemic-Onset Juvenile Idiopathic Arthritis

Examining the Role of Neutrophils in Systemic-Onset Juvenile Idiopathic Arthritis

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High neutrophil counts decreased after initiation of recombinant interleukin-1 receptor agonist therapy in systemic-onset juvenile idiopathic arthritis.

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

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Disease damage in patients with childhood-onset SLE is common, even with relatively short disease durations.

TNF Inhibitor Therapy Unlikely to Affect Malignancy Risk in Children

TNF Inhibitor Therapy Unlikely to Affect Malignancy Risk in Children

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Children with juvenile idiopathic arthritis, pediatric inflammatory bowel disease, and pediatric plaque psoriasis had an increased incidence of childhood malignancies, regardless of TNFi exposure.

Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse

Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse

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Abnormality on an ultrasound examination significantly increased the risk for flare in patients with juvenile idiopathic arthritis.

Predictors of Disability Assessed in Childhood-Onset Systemic Lupus Erythematosus

Predictors of Disability Assessed in Childhood-Onset Systemic Lupus Erythematosus

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Data from the CARRA Legacy Registry show disability is common in patients with childhood-onset SLE.

Improving Pediatric Rheumatic Disease Care With Consensus-Based Treatment Plans

Improving Pediatric Rheumatic Disease Care With Consensus-Based Treatment Plans

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The goal of consensus treatment plans is to drive a cycle of innovation and replacement that allows the addition of new treatments and the removal of unused or ineffective strategies.

Rheumatoid Arthritis Exposure In Utero Increases Chronic Disease Risk in Children

Rheumatoid Arthritis Exposure In Utero Increases Chronic Disease Risk in Children

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Maternal RA exposure in utero may increase the risk for certain chronic conditions, including RA, thyroid disease, and epilepsy.

More Severe Disease Found in Juvenile Myositis With Anti-NT5C1A Autoantibodies

More Severe Disease Found in Juvenile Myositis With Anti-NT5C1A Autoantibodies

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Autoantibodies that recognize cytosolic 5′-nucleotidase 1A were detected in about 25% of patients with juvenile myositis and juvenile idiopathic arthritis.

Choosing a Biologic Therapy for JIA: Etanercept vs Tocilizumab vs IL-1 Inhibitors

Choosing a Biologic Therapy for JIA: Etanercept vs Tocilizumab vs IL-1 Inhibitors

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Treatment response was most significant in patients taking either tocilizumab or an interleukin-1 inhibitor.

Inhaled Corticosteroid Use Not Associated With Fracture Risk in Pediatric Patients

Inhaled Corticosteroid Use Not Associated With Fracture Risk in Pediatric Patients

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Systemic but not inhaled corticosteroid use may be associated with increased fracture risk in pediatric patients.

Fluorescence Optical Imaging for Diagnosis of Pediatric Rheumatologic Conditions

Fluorescence Optical Imaging for Diagnosis of Pediatric Rheumatologic Conditions

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Chronic inflammatory rheumatologic diseases benefit from early anti-inflammatory treatment; however, interdisciplinary approaches may be necessary for identifying and managing noninflammatory joint pain.

Clinical Juvenile Arthritis Disease Activity Score Use in Treat-to-Target Therapy

Clinical Juvenile Arthritis Disease Activity Score Use in Treat-to-Target Therapy

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The objective of this study is to determine whether the JADAS or cJADAS would accurately predict patients with JIA in need of treatment escalation to anti-TNF after starting MTX.

Internet Intervention Improves Pain, QoL in Juvenile Idiopathic Arthritis

Internet Intervention Improves Pain, QoL in Juvenile Idiopathic Arthritis

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Psychoeducational treatments can aid in the transition to adult care, but this is often lacking for teens due to access issues.

Anti-Tumor Necrosis Factor Agents vs csDMARDs for Pediatric Enthesitis-Related Arthritis

Anti-Tumor Necrosis Factor Agents vs csDMARDs for Pediatric Enthesitis-Related Arthritis

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In children with enthesitis-related arthritis, the use of anti-tumor necrosis factor (TNF) agents within the first year of diagnosis has demonstrated benefits in several clinically meaningful outcomes.

Juvenile Idiopathic Arthritis Treated With Biologic Therapy: Risk Factors for Infection

Juvenile Idiopathic Arthritis Treated With Biologic Therapy: Risk Factors for Infection

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Patients with juvenile idiopathic arthritis under biologic therapy in a real-world setting have high rates of serious infections.

Femoral Stress Index is Associated with Fracture Risk in School Age Children

Femoral Stress Index is Associated with Fracture Risk in School Age Children

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The FSI proved to be at least as effective in predicting fracture risk in children as femoral and total body BMD.

New Assessment Tool Predicts Pediatric Fracture Risk

New Assessment Tool Predicts Pediatric Fracture Risk

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A new bone assessment evaluates fracture risk in children.

Juvenile Idiopathic Arthritis Increases Risk of Postpartum Complications

Juvenile Idiopathic Arthritis Increases Risk of Postpartum Complications

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Ongoing inflammation related to JIA may put first-time mothers at risk for complications.

Cardiovascular Risks in JIA Linked to Serum Vitamin D Level

Cardiovascular Risks in JIA Linked to Serum Vitamin D Level

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Thirty controls were compared with 30 patients with juvenile idiopathic arthritis to determine the link between vitamin D and CVD.

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

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This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.

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