Pediatric Rheumatology

Clinical Features Identified for Localized Scleroderma in Children

Clinical Features Identified for Localized Scleroderma in Children

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Researchers conducted a multicenter prospective study to identify clinical features characteristic of localized scleroderma in children.

Original vs Expanded Disease Activity Scoring System in JIA Examined

Original vs Expanded Disease Activity Scoring System in JIA Examined

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For a more precise assessment of disease activity and treatment effectiveness in individuals with JIA, inclusion of MCP joints should be considered in the scoring system.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

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Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Transitioning to Adult Health Care: Predictors of Preparedness in Adolescents With Arthritis

Transitioning to Adult Health Care: Predictors of Preparedness in Adolescents With Arthritis

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Female gender, older age, and higher patient activation scores predicted transition readiness in adolescent patients with arthritis.

Juvenile Spondyloarthritis Disease Activity Index Valid in Children With Enthesitis-Related Arthritis

Juvenile Spondyloarthritis Disease Activity Index Valid in Children With Enthesitis-Related Arthritis

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The Juvenile Spondyloarthritis Disease Activity Index is an appropriate measure of disease activity for enthesitis-related arthritis.

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

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Childhood-onset SLE has major effects on quality of life in adulthood.

Actemra SC Approved to Treat Active Systemic JIA

Actemra SC Approved to Treat Active Systemic JIA

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The FDA has approved Actemra SC for the treatment of active systemic JIA alone or in combination with methotrexate in patients ≥2 years old.

Evaluating Disease Activity Outcome Variables in Juvenile Dermatomyositis

Evaluating Disease Activity Outcome Variables in Juvenile Dermatomyositis

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The signs and symptoms associated with disease activity in juvenile dermatomyositis could be used to stratify patients and adapt treatment plans.

Juvenile Spondyloarthritis: Classification and Treatment Considerations

Juvenile Spondyloarthritis: Classification and Treatment Considerations

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Juvenile spondyloarthritis is a distinct form of childhood arthritis because of the male predominance, later age of onset, and involvement of the entheses and axial skeleton.

Ocular Complication Rates Improved With Biologic Use in Noninfectious Pediatric Uveitis

Ocular Complication Rates Improved With Biologic Use in Noninfectious Pediatric Uveitis

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Improvements in the rate of ocular complications and visual impairment have been noted in pediatric patients with noninfectious uveitis who are treated with biologic agents.

Examining Gaps in Mental Health Care Among Youth With Juvenile Rheumatic Disease

Examining Gaps in Mental Health Care Among Youth With Juvenile Rheumatic Disease

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There is an unmet need for mental health interventions that address illness-related issues affecting youth with rheumatologic conditions.

Diagnosing Lyme Disease in Children With Neuropsychiatric Illness

Diagnosing Lyme Disease in Children With Neuropsychiatric Illness

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Health professionals from many disciplines need to be able to recognize the clinical presentations, essential diagnostic tests, and treatment approach of Lyme neuroborreliosis.

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

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Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.

Novel MRI-Based Scoring System Assesses Disease Severity in Juvenile Dermatomyositis

Novel MRI-Based Scoring System Assesses Disease Severity in Juvenile Dermatomyositis

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The JDM Image Score may have the potential to serve as a reliable biomarker of disease severity and response to therapeutic interventions in children with juvenile dermatomyositis.

Clinical Assessment of Juvenile Idiopathic Arthritis: Predicting Unfavorable Long-Term Outcomes

Clinical Assessment of Juvenile Idiopathic Arthritis: Predicting Unfavorable Long-Term Outcomes

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Prediction models of outcomes in juvenile idiopathic arthritis have acceptable precision and require only readily available baseline variables.

Clinical Correlates of JIA Relapse After Biologic Therapy Discontinuation

Clinical Correlates of JIA Relapse After Biologic Therapy Discontinuation

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The investigators sought to evaluate the time patients were in remission after discontinuing biologic therapy for the treatment of JIA.

Actemra SC Approved to Treat Polyarticular Juvenile Idiopathic Arthritis

Actemra SC Approved to Treat Polyarticular Juvenile Idiopathic Arthritis

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The FDA has approved the subcutaneous formulation of Actemra for the treatment of active polyarticular juvenile idiopathic arthritis.

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

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Baseline depressive symptoms were associated with pain and disability in adolescents with juvenile idiopathic arthritis.

Efficacy, Safety of Adalimumab vs Infliximab in JIA-Associated Uveitis

Efficacy, Safety of Adalimumab vs Infliximab in JIA-Associated Uveitis

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Researchers evaluated the safety and efficacy of adalimumab and infliximab in the treatment of juvenile idiopathic arthritis-associated uveitis in patients treated for at least 2 years.

Amendment Added to OMERACT Ultrasound Definition of Healthy Pediatric Joints

Amendment Added to OMERACT Ultrasound Definition of Healthy Pediatric Joints

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Researchers sought to include Doppler findings in the evaluation and definition of normal joint features that can be visualized in healthy children in different age groups.

Treatment Targets in JIA: Comparing Definitions of Clinically Inactive Disease

Treatment Targets in JIA: Comparing Definitions of Clinically Inactive Disease

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Investigators aimed to examine the use of treatment targets in juvenile idiopathic arthritis in terms of joint limitations, functional ability, psychosocial health, and pain levels.

Managing Uveitis in Juvenile Idiopathic Arthritis: Consensus-Based Recommendations

Managing Uveitis in Juvenile Idiopathic Arthritis: Consensus-Based Recommendations

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The SHARE initiative has provided recommendations for the diagnosis and treatment of juvenile idiopathic arthritis-associated uveitis.

Clinical Features Identified in Enthesitis-Related Juvenile Idiopathic Arthritis, Juvenile Spondyloarthritis

Clinical Features Identified in Enthesitis-Related Juvenile Idiopathic Arthritis, Juvenile Spondyloarthritis

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Results confirm that juvenile spondyloarthritis is characterized by its peripheral pattern at disease onset, with peripheral arthritis and enthesitis.

Ultrasound Not Predictive of Disease Flares for Inactive Juvenile Idiopathic Arthritis

Ultrasound Not Predictive of Disease Flares for Inactive Juvenile Idiopathic Arthritis

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Abnormal ultrasound findings were common in patients with juvenile idiopathic arthritis with clinically inactive disease.

Flare Risk Examined in Juvenile Idiopathic Arthritis After Anti-TNF Therapy Discontinuation

Flare Risk Examined in Juvenile Idiopathic Arthritis After Anti-TNF Therapy Discontinuation

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Researchers sought to determine the predictors of disease flare after anti-TNF therapy discontinuation in children with polyarticular forms of juvenile idiopathic arthritis with sustained clinically inactive disease.

Examining the Role of Neutrophils in Systemic-Onset Juvenile Idiopathic Arthritis

Examining the Role of Neutrophils in Systemic-Onset Juvenile Idiopathic Arthritis

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High neutrophil counts decreased after initiation of recombinant interleukin-1 receptor agonist therapy in systemic-onset juvenile idiopathic arthritis.

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

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Disease damage in patients with childhood-onset SLE is common, even with relatively short disease durations.

TNF Inhibitor Therapy Unlikely to Affect Malignancy Risk in Children

TNF Inhibitor Therapy Unlikely to Affect Malignancy Risk in Children

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Children with juvenile idiopathic arthritis, pediatric inflammatory bowel disease, and pediatric plaque psoriasis had an increased incidence of childhood malignancies, regardless of TNFi exposure.

Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse

Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse

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Abnormality on an ultrasound examination significantly increased the risk for flare in patients with juvenile idiopathic arthritis.

Predictors of Disability Assessed in Childhood-Onset Systemic Lupus Erythematosus

Predictors of Disability Assessed in Childhood-Onset Systemic Lupus Erythematosus

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Data from the CARRA Legacy Registry show disability is common in patients with childhood-onset SLE.

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