Ixekizumab Compared With Adalimumab in Head-to-Head PsA Study

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No new safety signals were detetced in SPIRIT-H2H.
No new safety signals were detetced in SPIRIT-H2H.

Ixekizumab (Taltz; Lilly) was found to be superior in improving the signs and symptoms of active psoriatic arthritis (PsA) in biologic disease-modifying anti-rheumatic drug (DMARD)-naive patients compared with adalimumab (Humira; AbbVie), according to results of a Phase 3b/4 study.

The SPIRIT-H2H trial (N=566) randomized PsA patients to receive ixekizumab (160mg starting dose followed by 80mg every 4 weeks) or adalimumab (40mg every 2 weeks) for 52 weeks; patients with moderate-to-severe plaque psoriasis received the approved dose of ixekizumab or adalimumab for that indication. The primary endpoint was simultaneous achievement of at least a 50-percent reduction in disease activity, as defined by the American College of Rheumatology (ACR50), as well as complete skin clearance as measured by the Psoriasis Area and Severity Index (PASI100). 

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Results showed that ixekizumab was found to be superior to adalimumab in improving PsA, meeting the primary endpoint at week 24. The full results are expected at a scientific meeting sometime in 2019.

Eli Lilly and Company sponsored the study.

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For more information visit ClinicalTrials.gov.

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