Rheumatoid Arthritis Headlines

No Clinically Meaningful Safety Differences Between Sarilumab, Tocilizumab in RA

No Clinically Meaningful Safety Differences Between Sarilumab, Tocilizumab in RA

Sarilumab and tocilizumab have shown no clinically relevant differences in safety and tolerability outcomes.

Biologic Therapies in JIA: International Registry Data Combined

Biologic Therapies in JIA: International Registry Data Combined

National and international pharmacovigilance registry data pertaining to the use of biologic agents in patients with juvenile idiopathic arthritis have been combined.

Vitamin D Deficiency Linked to Uveitis, Disease Activity in Juvenile Idiopathic Arthritis

Vitamin D Deficiency Linked to Uveitis, Disease Activity in Juvenile Idiopathic Arthritis

Vitamin D deficiency was common and associated with higher disease activity and risk for juvenile idiopathic arthritis-associated uveitis.

Tender Joint Count May Not Reflect Inflammation Activity in Rheumatoid Arthritis

Tender Joint Count May Not Reflect Inflammation Activity in Rheumatoid Arthritis

The inclusion of tender joint count in the Composite Disease Activity Score may contribute to misleading information about inflammatory activity.

Increased Risk for Cancer Observed in Abatacept-Treated Rheumatoid Arthritis

Increased Risk for Cancer Observed in Abatacept-Treated Rheumatoid Arthritis

The use of abatacept as an initial bDMARD for the treatment of patients with rheumatoid arthritis is associated with a slightly elevated risk for cancer overall.

Evaluating Associations of Financial Conflicts of Interest With RA Drug Trial Outcomes

Evaluating Associations of Financial Conflicts of Interest With RA Drug Trial Outcomes

Researchers examined the prevalence, types, and temporal trends of financial conflicts of interest among authors of drug therapy randomized controlled trials for RA.

Increased Prevalence of RA-Related Interstitial Lung Disease Noted in the United States

Increased Prevalence of RA-Related Interstitial Lung Disease Noted in the United States

The prevalence of rheumatoid arthritis-related interstitial lung disease has increased over the 10-year period from 2004 to 2013.

NDA Submitted for Investigational Rheumatoid Arthritis Treatment

NDA Submitted for Investigational Rheumatoid Arthritis Treatment

AbbVie has submitted a New Drug Application to the FDA for upadacitinib, their investigational oral treatment for rheumatoid arthritis.

RA Flare Risk Not Predicted by Adalimumab Trough, Antibody Levels

RA Flare Risk Not Predicted by Adalimumab Trough, Antibody Levels

Flare risk within the year after adalimumab discontinuation was not predicted by trough or antibody levels.

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Phone-Based Intervention Aids Rheumatoid Arthritis Care

A nurse-based phone education intervention can promote shared decision making in patients with newly diagnosed rheumatoid arthritis.

BLA Submitted for Biosimilar Candidate to Remicade

BLA Submitted for Biosimilar Candidate to Remicade

Amgen has submitted a Biologics License Application (BLA) for ABP 710, a biosimilar to infliximab (Remicade).

Gene Polymorphisms Predict Response to Tocilizumab, Rituximab in RA

Gene Polymorphisms Predict Response to Tocilizumab, Rituximab in RA

The presence of the FCGR2A rs1801274-TT genotype and FCGR3A rs396991-G allele may act as significant predictors of response to tocilizumab and rituximab therapy in RA.

Elderly Patients Underrepresented in Clinical Trials for Rheumatoid Arthritis, Osteoarthritis

Elderly Patients Underrepresented in Clinical Trials for Rheumatoid Arthritis, Osteoarthritis

Data show that the elderly are underrepresented in randomized clinical trials for rheumatoid arthritis and osteoarthritis.

Improving RA Diagnosis With Use of Anti-ACPAs

Improving RA Diagnosis With Use of Anti-ACPAs

In patients with rheumatoid arthritis, the use of multiple antibody assays may improve clinical diagnosis and disease management.

Ultrasound May Be Reliable for Assessing Subtalar Joint Synovitis in Rheumatoid Arthritis

Ultrasound May Be Reliable for Assessing Subtalar Joint Synovitis in Rheumatoid Arthritis

Data show that ultrasound is a reliable means of evaluating subtalar joint synovitis in patients with rheumatoid arthritis.

Bone Erosions More Frequent With Old Age at Onset of Early RA

Bone Erosions More Frequent With Old Age at Onset of Early RA

Old age at onset of early rheumatoid arthritis is associated with more frequent bone erosions.

Single-Dose Prefilled Autoinjector for Actemra Approved

Single-Dose Prefilled Autoinjector for Actemra Approved

Genentech announced that the FDA has approved ACTPen autoinjector for Actemra as a new formulation for adults with moderate to severe active RA.

Functional Disability Progression More Rapid in Postmenopausal Women With RA

Functional Disability Progression More Rapid in Postmenopausal Women With RA

Functional disability progressed more rapidly in postmenopausal compared with premenopausal women with rheumatoid arthritis.

Rituximab Biosimilar Shows Similar Safety to Reference Biologic in RA

Rituximab Biosimilar Shows Similar Safety to Reference Biologic in RA

The safety of switching from reference rituximab to the rituximab biosimilar was comparable to continuation of reference rituximab.

Factors Affecting Hand Function, Disability in Rheumatoid Arthritis

Factors Affecting Hand Function, Disability in Rheumatoid Arthritis

Data highlight a lack of consideration of personal and environmental factors when studying the effects of RA on hand function.