Scleroderma

Novel Blood Test May Aid Scleroderma Diagnosis and Risk Stratification

Novel Blood Test May Aid Scleroderma Diagnosis and Risk Stratification

Mark Pimentel, MD, discusses the release of a new blood test that may aid in the diagnosis of scleroderma and systemic sclerosis.

Systemic Sclerosis-Associated PAH Genomic Signature Differs From ILD

Systemic Sclerosis-Associated PAH Genomic Signature Differs From ILD

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Systemic sclerosis-associated pulmonary hypertension and systemic sclerosis-associated interstitial lung disease exhibit similar but distinct gene expression profiles.

Ulnar Artery Occlusion: A Vasculopathy Severity Marker in SSc

Ulnar Artery Occlusion: A Vasculopathy Severity Marker in SSc

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Ulnar artery occlusion may function as a relevant marker of vasculopathy severity in systematic sclerosis.

Severe Gastrointestinal Disease in Early Systemic Sclerosis Linked to Increased Morbidity, Mortality

Severe Gastrointestinal Disease in Early Systemic Sclerosis Linked to Increased Morbidity, Mortality

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Severe gastrointestinal disease is common in early systemic sclerosis, and is linked to increased mortality.

Increased Prevalence of Systemic Sclerosis Observed in the United Kingdom

Increased Prevalence of Systemic Sclerosis Observed in the United Kingdom

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Researchers estimated the incidence and prevalence of systemic sclerosis in recent years in the United Kingdom.

Exercise Oxygen Desaturation, Pulmonary Function Predict Outcomes in SSc-PH

Exercise Oxygen Desaturation, Pulmonary Function Predict Outcomes in SSc-PH

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Factors associated with a higher risk for mortality included male sex, exercise desaturation, and diffusing capacity of the lungs for carbon monoxide <50%.

Short-Term Progression of Interstitial Lung Disease in Systemic Sclerosis Predictive of Long-Term Survival

Short-Term Progression of Interstitial Lung Disease in Systemic Sclerosis Predictive of Long-Term Survival

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A decline in FVC and DLCO over 2 years was a better predictor of mortality than baseline FVC and DLCO.

On-Demand Sildenafil May Be Promising Second-Line Treatment for Raynaud Phenomenon

On-Demand Sildenafil May Be Promising Second-Line Treatment for Raynaud Phenomenon

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Results did not show that on-demand sildenafil was more effective than placebo from a clinical standpoint.

Clinical Features Identified for Localized Scleroderma in Children

Clinical Features Identified for Localized Scleroderma in Children

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Researchers conducted a multicenter prospective study to identify clinical features characteristic of localized scleroderma in children.

Depression Prevalent Among Individuals With Systemic Sclerosis

Depression Prevalent Among Individuals With Systemic Sclerosis

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Depression is prevalent in a considerable proportion of patients with systemic sclerosis.

Ultrasonographic Synovial Involvement Frequent in Systemic Sclerosis

Ultrasonographic Synovial Involvement Frequent in Systemic Sclerosis

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Ultrasonographic synovial involvement is frequent in patients with systemic sclerosis.

Gene Therapy for Localized Scleroderma Gets FDA's Fast Track Designation

Gene Therapy for Localized Scleroderma Gets FDA's Fast Track Designation

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Clinical enrollment for an open-label, single-arm Phase 1/2 trial of FCX-013 was initiated in August 2018.

Rituximab Safe and Efficacious Alternative Treatment for Scleroderma

Rituximab Safe and Efficacious Alternative Treatment for Scleroderma

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Rituximab is a safe and effective alternative to cyclophosphamide in managing the progression of scleroderma and subsequent development of interstitial lung disease.

Older Age Associated With Greater Cardiac Involvement in Early Systemic Sclerosis

Older Age Associated With Greater Cardiac Involvement in Early Systemic Sclerosis

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In patients in the early stages of systemic sclerosis, older patients had more severe disease with greater cardiac involvement.

Risk Factors for Scleroderma Renal Crisis in Systemic Sclerosis

Risk Factors for Scleroderma Renal Crisis in Systemic Sclerosis

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Researchers identify risk factors for scleroderma renal crisis in patients with systemic sclerosis.

Strong Reproducibility for 6-Minute Walk Test in Systemic Sclerosis

Strong Reproducibility for 6-Minute Walk Test in Systemic Sclerosis

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Investigators assessed the reproducibility and the utility of the 6-minute walk test in systemic sclerosis.

Little Data Available for Small Intestinal Bacterial Overgrowth Treatment in Systemic Sclerosis

Little Data Available for Small Intestinal Bacterial Overgrowth Treatment in Systemic Sclerosis

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For some patients with systemic sclerosis, antibiotics can eradicate small intestinal bacterial overgrowth.

SPAR Model May Predict Mild Interstitial Lung Disease in Systemic Sclerosis

SPAR Model May Predict Mild Interstitial Lung Disease in Systemic Sclerosis

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The SPAR prediction model might be helpful for the risk stratification of mild ILD in patients with SSc in clinical practice.

PAH in Systemic Sclerosis Increases Risk for Early Mortality

PAH in Systemic Sclerosis Increases Risk for Early Mortality

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The majority of deaths in patients with systemic sclerosis-associated pulmonary arterial hypertension occurred within 4 years of diagnosis.

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

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There was no significant difference in efficacy between sildenafil and bosentan initial combination therapy and sildenafil monotherapy in patients with systemic sclerosis-related pulmonary arterial hypertension.

Smoking Not Associated With Systemic Sclerosis-Specific Cutaneous, Pulmonary Manifestations

Smoking Not Associated With Systemic Sclerosis-Specific Cutaneous, Pulmonary Manifestations

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Smoking status in patients with systemic sclerosis was not significantly associated with systemic sclerosis-specific cutaneous or pulmonary changes.

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

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Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

LPA1 Receptor Antagonist SAR100842 Safe, Well Tolerated in Systemic Sclerosis

LPA1 Receptor Antagonist SAR100842 Safe, Well Tolerated in Systemic Sclerosis

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The investigational drug SAR100842 was safe, moderately effective, and well tolerated in patients with early diffuse cutaneous systemic sclerosis.

Expert Insight: Detecting Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

Expert Insight: Detecting Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

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Although pulmonary arterial hypertension occurs in a minority of patients with systemic sclerosis, clinicians must be attentive to it, as it can emerge at any point over the course of the disease.

Scleroderma Phenotype, Autoantibodies May Identify Patients at Risk for Cancer

Scleroderma Phenotype, Autoantibodies May Identify Patients at Risk for Cancer

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Stratification by clinical features and autoantibody response identify scleroderma subgroups with distinct risks for cancer.

Independent Predictors of VTE Identified in Systemic Sclerosis

Independent Predictors of VTE Identified in Systemic Sclerosis

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Researchers evaluated the prevalence, risk factors, and effect of venous thromboembolism on survival in systemic sclerosis.

Predicting Skin Score Changes in Early Diffuse Systemic Sclerosis

Predicting Skin Score Changes in Early Diffuse Systemic Sclerosis

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Two predictive models for progressive skin thickening in patients with early diffuse cutaneous systemic sclerosis were developed to use in clinical practice and to improve recruitment in clinical trials.

Social Anxiety in Systemic Sclerosis: Comparing Patient Assessment Tools

Social Anxiety in Systemic Sclerosis: Comparing Patient Assessment Tools

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Investigators assessed 3 versions of the Brief Fear of Negative Evaluation scale in patients with systemic sclerosis.

Scleroderma and Breast Cancer: Examining Outcomes of Radiation Therapy

Scleroderma and Breast Cancer: Examining Outcomes of Radiation Therapy

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Researchers sought to determine the prevalence of radiation complications in patients with systemic scleroderma and breast cancer.

Stem Cell Transplant May Benefit Patients With Systemic Sclerosis

Stem Cell Transplant May Benefit Patients With Systemic Sclerosis

Patients who underwent autologous hematopoietic stem cell transplant for systemic sclerosis saw improvements in quality of life.

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