Spondyloarthritis

Increased HLA-B27 Associated With More Severe Sonographic Enthesitis in PsA

Increased HLA-B27 Associated With More Severe Sonographic Enthesitis in PsA

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In patients with psoriatic arthritis, increasing levels of HLA-B27 are associated with more severe sonographic enthesitis.

Functional Status in Early Axial Spondyloarthritis: The Role of Spinal Structural Damage

Functional Status in Early Axial Spondyloarthritis: The Role of Spinal Structural Damage

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Results of the GESPIC study found that structural damage in the spine and disease activity were both determinants of functional status and spine mobility in patients with early axial spondyloarthritis.

Sustained Reduction in axSpA Joint Inflammation With Certolizumab Pegol

Sustained Reduction in axSpA Joint Inflammation With Certolizumab Pegol

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Decreases in spinal and sacroiliac joint inflammation on MRI were maintained through 204 weeks with certolizumab pegol treatment.

Spondyloarthritis Increases Risk for Dysrhythmias and Aortic Regurgitation

Spondyloarthritis Increases Risk for Dysrhythmias and Aortic Regurgitation

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The risk for aortic regurgitation and cardiac rhythm abnormalities was evaluated in a nationwide cohort of patients with spondyloarthritis.

Efficacy and Safety of Ixekizumab Evaluated in Active Psoriatic Arthritis

Efficacy and Safety of Ixekizumab Evaluated in Active Psoriatic Arthritis

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Results from the phase 3 SPIRIT-P1 study show that treatment with ixekizumab every 2 or 4 weeks in patients with active psoriatic arthritis demonstrated sustained efficacy and a favorable safety profile.

Efficacy of Apremilast Monotherapy Assessed in Biologic-Naive Psoriatic Arthritis

Efficacy of Apremilast Monotherapy Assessed in Biologic-Naive Psoriatic Arthritis

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Patients with psoriatic arthritis who are taking apremilast experienced early symptom relief and sustained clinical improvement through 1 year of treatment.

Biologic DMARDs Do Not Reduce Spinal Fracture Risk in Ankylosing Spondylitis

Biologic DMARDs Do Not Reduce Spinal Fracture Risk in Ankylosing Spondylitis

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Spinal fracture-free survival among patients with AS was not significantly affected by the use of bDMARD therapy.

Update: 2017 Treat-to-Target Recommendations for Spondyloarthritis

Update: 2017 Treat-to-Target Recommendations for Spondyloarthritis

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In an update to recommendations from 2012, an international task force conducted a systematic evidence review of data from the last 5 years.

What Is the Best Site for Assessing Bone Loss in Ankylosing Spondylitis?

What Is the Best Site for Assessing Bone Loss in Ankylosing Spondylitis?

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Research suggests that the best site to assess bone loss in patients with ankylosing spondylitis is the femoral neck.

Diagnostic Value of Repeat MRI in Suspected Early Axial Spondyloarthritis

Diagnostic Value of Repeat MRI in Suspected Early Axial Spondyloarthritis

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The diagnostic utility of repeat MRI was examined in people who were HLA-B27-negative or positive.

Examining Smoking Paradox in PsA Development for Patients With Psoriasis

Examining Smoking Paradox in PsA Development for Patients With Psoriasis

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Smoking is positively associated with the risk for PsA in the general population, but negatively associated with PsA in patients with psoriasis.

Psoriatic Arthritis Questionnaire Reliable, Feasible in Clinical Practice

Psoriatic Arthritis Questionnaire Reliable, Feasible in Clinical Practice

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The Psoriatic Arthritis Impact of Disease Questionnaire is a reliable patient-reported outcome measure with utility among patients with psoriatic arthritis in clinical practice.

Discontinuation of Biosimilar Infliximab Associated With Subjective Complaints

Discontinuation of Biosimilar Infliximab Associated With Subjective Complaints

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Transitioning from an originator agent to its biosimilar has the potential to reduce healthcare costs without compromising outcomes.

Etanercept for Spondyloarthritis: Impact on Disease Progression

Etanercept for Spondyloarthritis: Impact on Disease Progression

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The use of tumor necrosis factor inhibitors to modify structural changes in axial spondyloarthritis may prevent progression to spinal disease.

Endothelial Function Improves With Methotrexate, Anti-TNF Therapy in Inflammatory Arthritis

Endothelial Function Improves With Methotrexate, Anti-TNF Therapy in Inflammatory Arthritis

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Although the effect of antirheumatic drugs on inflammatory arthritic conditions has not been fully elucidated, treatment with methotrexate and tumor necrosis factor inhibitors has been found to improve endothelial dysfunction in this population.

Bone Marrow Edema in Sacroiliac Joints Common Among Young Athletes

Bone Marrow Edema in Sacroiliac Joints Common Among Young Athletes

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Researchers sought to learn more about the "background noise" of MRI features in the sacroiliac joints of young athletes.

Secukinumab Long-Term Reduction of Radiographic Progression in Ankylosing Spondylitis

Secukinumab Long-Term Reduction of Radiographic Progression in Ankylosing Spondylitis

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For patients with ankylosing spondylitis, secukinumab may reduce radiographic progression and remain effective in the long-term.

Ankylosing Spondylitis Associated With Higher Risk for Cardiovascular Events

Ankylosing Spondylitis Associated With Higher Risk for Cardiovascular Events

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The risk for cerebrovascular accidents and myocardial infarctions was assessed in patients with ankylosing spondylitis.

Axial Spondyloarthritis Classification Using Sacroiliac Joint MRI

Axial Spondyloarthritis Classification Using Sacroiliac Joint MRI

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MRI examination of structural lesions of the sacroiliac joints and the spine may help identify and classify axial spondyloarthritis.

Inflammation of Sacroiliac Joint in Axial Spondyloarthritis vs Healthy Participants

Inflammation of Sacroiliac Joint in Axial Spondyloarthritis vs Healthy Participants

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Inflammation shown on MRI of the sacroiliac joint (MRI-SI) is prevalent in axSpA (±30%), but the specificity is not well known.

Abatacept Improves Outcomes in Patients With Active Psoriatic Arthritis

Abatacept Improves Outcomes in Patients With Active Psoriatic Arthritis

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Administration of abatacept may improve patient-reported outcomes in individuals with active psoriatic arthritis and elevated levels of C-reactive protein, irrespective of tumor necrosis factor inhibitor treatment history.

Draft Psoriatic Arthritis Guideline Presented at ACR 2017

Draft Psoriatic Arthritis Guideline Presented at ACR 2017

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The guideline includes recommendations for treating adult patients with active psoriatic arthritis.

Secukinumab Effective for Inhibiting Radiographic Progression in PsA

Secukinumab Effective for Inhibiting Radiographic Progression in PsA

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Regardless of dose, patients taking secukinumab were more likely to experience no radiographic progression compared with placebo.

TNF Inhibitors Decrease Extraarticular Manifestations in Ankylosing Spondylitis

TNF Inhibitors Decrease Extraarticular Manifestations in Ankylosing Spondylitis

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Treatment with TNF inhibitors has led to improvement in physical function and quality of life in patients with ankylosing spondylitis.

Tofacitinib Improves Patient-Reported Outcomes for Active Psoriatic Arthritis

Tofacitinib Improves Patient-Reported Outcomes for Active Psoriatic Arthritis

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Results from phase 3 trials OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439) presented at the American College of Rheumatology 2017 in San Diego, California.

Local Inflammation Predicts Structural Damage in Axial Spondyloarthritis

Local Inflammation Predicts Structural Damage in Axial Spondyloarthritis

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Researchers recruited patients with recent onset axial spondyloarthritis and conducted MRI of the spine or MRI of the sacroiliac joints at baseline, 2 years, and 5 years.

Therapeutic Goal Achievement Independent of Cardiovascular Risk in Psoriatic Arthritis

Therapeutic Goal Achievement Independent of Cardiovascular Risk in Psoriatic Arthritis

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With the exception of sedentary lifestyle, cardiovascular risk factors were not found to impact the likelihood of achieving minimal disease activity among patients with psoriatic arthritis.

Higher Prevalence of Depression, ADHD Observed Among Women With Psoriatic Arthritis

Higher Prevalence of Depression, ADHD Observed Among Women With Psoriatic Arthritis

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Researchers observed a higher prevalence of psychiatric disorders among female patients with psoriatic arthritis.

High BMI, Obesity Predict Worse Disease Outcomes in Axial Spondyloarthropathy

High BMI, Obesity Predict Worse Disease Outcomes in Axial Spondyloarthropathy

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Recognition of the negative consequences of being obese is vital to effectively managing axial spondyloarthropathy.

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

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Real-world data indicate that although most patients with systemic lupus erythematosus or connective tissue diseases have successful pregnancies, more adverse pregnancy outcomes occur.

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