Systemic Lupus Erythematosus News Archive
Results from a phase 2 study suggest that ustekinumab might be an effective therapy in systemic lupus erythematosus.
Patients with systemic lupus erythematosus have a high risk for postoperative complications and mortality following major surgery compared with patients without SLE.
Patient-reported outcomes are independent predictors of mortality in systemic lupus erythematosus.
Vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.
Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.
Childhood-onset SLE has major effects on quality of life in adulthood.
The use of validated disease activity and damage metrics is important in the assessment of SLE.
Cigarette smoking was associated with an increased SLE risk and alcohol consumption was associated with decreased SLE risk.
Prolonged antimalarial therapy and persistent creatine phosphokinase elevation resulted in an increased risk for abnormal brain natriuretic peptide and cardiac troponin.
Patients with systemic lupus erythematosus have a high prevalence of subclinical myocardial injury, as evidenced by raised high-sensitive troponin levels.
Patients with early SLE had higher rates of unexplained fever than those with SLE-mimicking conditions.
Lupus nephritis in combination with impaired renal function is strongly associated with the presence of atherosclerosis in patients with systemic lupus erythematosus.
Researchers investigated the characteristics and outcomes of patients with systemic lupus erythematosus-associated thrombotic microangiopathy based on their ADAMTS13 inhibitor profiles.
The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, such as intrauterine grown restriction and preeclampsia.
The incidence of zoster is high in systemic vasculitis and in patients with SLE exposed to intravenous cyclophosphamide.
Patients with SSc-SLE overlap syndrome were younger at diagnosis, had higher rates of pulmonary arterial hypertension, and less frequently had SSc cutaneous manifestations.
The risk for depression was increased significantly in patients with systemic lupus erythematosus and cutaneous lupus erythematosus.
Data indicate that drug-naive new onset systemic lupus erythematosus was likely to involve silent cardiac impairment.
Poor preconception cardiovascular health affects pregnancy outcomes in women with SLE.
The burden of entheseal sonographic changes was significantly higher in patients with SLE vs healthy participants, especially with respect to active inflammation.
Investigators sought to identify the risk factors for osteonecrosis and to identify the minimal investigations needed to monitor the risk for osteonecrosis in patients with systemic lupus erythematosus.
Researchers sought to assess the prevalence and characteristics of monophasic disease course in a defined cohort of patients with SLE.
Routinely available serologic markers have no correlation with tubulointerstitial damage in patients with lupus nephritis.
Erythrocyte-bound C4d may be useful in monitoring systemic lupus erythematosus.
Outcomes in systemic lupus erythematosus are largely influenced by level of poverty, type of neighborhood of residence, and chronic stress.
Investigators sought to evaluate changes in demographic, clinical, and histologic presentation in patients with lupus nephritis between 1970 and 2016.
Female patients with systemic lupus erythematosus who had musculoskeletal symptoms or positive antiphospholipid antibodies demonstrated higher titers of anti-double-stranded DNA antibodies.
Patients with systemic lupus erythematosus exhibit increased central arterial stiffness compared with a healthy control population.
The relationship between pain and cognitive dysfunction was explained by sleep disturbance and depressive symptoms.
Bisphosphonates and vitamin D may help prevent atherosclerosis in patients with systemic lupus erythematosus.
Provisional criteria for global flares in patients with childhood-onset systemic lupus erythematosus are now available from the ACR.
Researchers compared the clinical, laboratory, and treatment characteristics of antiphospholipid antibody-positive patients with or without SLE.
Data show that anti-ENA results change infrequently, especially following 1 or more negative tests.
A 72-year-old Japanese woman with a 40-year history of lupus nephritis presented with leg edema that had lasted for several weeks.
Weekly belimumab treatment was safe and effective and superior to placebo for reducing disease activity over 52 weeks in patients who were hypocomplementemic and anti-dsDNA positive.
Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.
Certain clinical and serological markers were predictive of future incident proteinuria in patients with systemic lupus erythematosus.
Systemic lupus erythematosus is among the top 20 leading causes of death in women between the ages of 5 and 64 years in the United States.
Investigators suggest several mechanisms for the contribution of poverty to high mortality rates in patients with systemic lupus erythematosus.
Researchers compared the quality of care received by patients with systemic lupus erythematosus in 2 settings within the same academic institution.
The Epstein-Barr virus EBNA2 protein and many coclustering human transcription factors occupied nearly half of SLE risk loci.
The frequency of metabolic syndrome among patients with SLE was approximately 45%.
Blisibimod was effective in patients with SLE in terms of steroid reduction, decreased proteinuria, and improvement in serological markers.
Neutrophil extracellular traps contain ubiquitinated proteins with a lower expression of polyubiquitinated proteins in patients with SLE.
Researchers examined differences in the ability to get pregnant in women with systemic lupus erythematosus and rheumatoid arthritis.
Ofatumumab was a well-tolerated, safe, and effective alternative to rituximab for B cell depletion therapy.
The IL-19 risk allele is associated with stroke and myocardial infarction in patients with systemic lupus erythematosus and rheumatoid arthritis, but not in the general population.
Remission status was a significant and useful predictor of renal survival, in patients with lupus nephritis.
Researchers investigated serum IgG anti-MDA expression and associations with disease activity in patients with systemic lupus erythematosus.
Results from the MUSE trial show that lupus low disease activity state attainment in patients with systemic lupus erythematosus is a clinically meaningful disease outcome measure.
Researchers used phenotype-wide association studies to uncover associations in men and women with systemic lupus erythematosus.
Researchers found that disease flare incidence in women with SLE increased during pregnancy and within 3 months postpartum.
No significant differences were observed in the incidence of ESRD and mortality among men vs women with lupus nephritis.
Disease damage in patients with childhood-onset SLE is common, even with relatively short disease durations.
Epratuzumab improved systemic lupus erythematosus disease activity in patients with associated Sjogren syndrome.
Researchers examined the proportion of Medicaid patients with systemic lupus erythematosus who receive baseline retinal examinations when initiating treatment with hydroxychloroquine.
The PROMIS10 patient-reported outcome measure is a valid and reliable tool in routine systemic lupus erythematosus care.
In patients with primary antiphospholipid syndrome, the presence of phosphatidylserine/prothrombin complex antibodies is associated with Raynaud phenomenon and migraine.
Complement pathway activation is associated with adverse pregnancy outcomes in women with systemic lupus erythematosus or antiphospholipid antibodies.
Data from the CARRA Legacy Registry show disability is common in patients with childhood-onset SLE.
Smoking is associated with risk for development of the anti-double-stranded DNA positive subtype of systemic lupus erythematosus.
The frequency, attribution, clinical, and autoantibody status of patients with lupus who developed cerebrovascular events are reported in this study.
Future research should look to improve perioperative management in people with systemic lupus erythematosus.
At this time, no serological test can distinguish neuropsychiatric events resulting from SLE activity from events resulting from other causes.
The risk for asthma may be increased in children born to mothers with systemic lupus erythematosus during pregnancy.
Patients with primary antiphospholipid syndrome and systemic lupus erythematosus-associated antiphospholipid syndrome have an almost 2.5-fold risk for development of atherosclerotic plaques in carotid and femoral arteries compared with healthy control patients.
Older patients with SLE are at a low risk for the development of proteinuria.
Lupus low disease activity state has been shown to be achievable and negatively associated with early damage accrual.
Investigators evaluated long-term outcomes with antimalarial use and organ damage, flares, disease activity, glucocorticoid use, and antimalarial associated retinopathy.
The SHARE initiative has formulated evidence-based recommendations for the diagnosis and treatment of lupus nephritis childhood-onset lupus nephritis.
Maternal systemic lupus erythematosus during pregnancy is associated with increased risk for asthma in children.
Switching from 1 antimalarial agent to a second may be beneficial in patients with cutaneous lupus erythematosus.
Atacicept may be safe and effective for lowering disease activity and severity in patients with active systemic lupus erythematosus.
Rates of SLE mortality have declined, but remain high relative to non-SLE mortality.
Anti-ficolin-2 autoantibodies may represent a biomarker for renal manifestations in patients with active systemic lupus erythematosus.
The efficacy variables with the greatest effect on systemic lupus erythematous (SLE) Responder Index responder status in clinical trials include SLE Disease Activity Index improvement, concomitant medication adherence, and trial completion.
The recurrence of fetal cardiac conduction disturbances in the fetuses of women expressing anti-Ro/SSA antibodies may be influenced by the season of the year and maternal age.
While a treat to target strategy has been proposed for managing SLE, the impact of possible disease outcomes has not been fully evaluated.
Current smoking and >10 pack-years of smoking have demonstrated a strong and specific association with an increased risk for occurrence of anti-double-stranded DNA systemic lupus erythematosus.
In patients with SLE, 62.1% did not adhere to their medication regimens and 35% of patients demonstrated a depressed mood.
Identification of the biologic pathways by which psychosocial trauma may increase a woman's risk for autoimmune disorders is critical and may offer greater insight into disease etiology and strategies for prevention.
Systemic Lupus Erythematosus-Associated Cognitive Impairment May Be Identified With New Screening Tool
The high prevalence of cognitive impairment in patients with SLE creates a need for a reliable and cost-effective screening tool.
Research confirmed the increased burden of SLE in black, Asian, and Hispanic women compared with white women.
Research revealed that hydroxychloroquine is associated with reduced LDL-C and total cholesterol levels in patients with lupus.
More than 25% of SLE patients also have metabolic syndrome.
Mannose-binding lectin of the complement system may contribute to the development of clinical manifestations in SLE.
The SHARE initiative established guidelines on cSLE, which is a rare disorder.
The development of lupus nephritis is associated with significant morbidity and mortality.
This study finds that a cardiovascular disease prevention counseling program decreases the prevalence of cardiovascular disease risk factors in patients with systemic lupus erythematosus.
Rituximab non-responders may still be amenable to B-cell targeted therapies, such as ofatumumab or obinutuzumab.
The risk of developing SLE in current statin users aged ≥40 years was no different than that in nonusers.
Use of the anti-apoptotic protein B-cell lymphoma 2 inhibitor venetoclax reduced total lymphocyte and disease-relevant B cells in women with SLE.
SLE was low to absent in pregnant women during conception and pregnancy, but increased after delivery.
Researchers have created a set of 21 candidate criteria for SLE as part of a multiphase development of a set of criteria for the disease.
FENO monitoring may provide a biomarker of disease activity and signify the emergence of pulmonary involvement in kids with SLE.
Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus
Long-term hydroxychloroquine use, combined with low-dose aspirin, protected against thrombosis in patients with systemic lupus erythematosus.
This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.
Increased disease activity, poorer physical functioning, and lower education attainment were major predictors for depression in adulthood.
Meta-analysis supports anti-RNP and anti-Sm antibodies as serological biomarkers of PAH risk in patients with systemic lupus erythematosus.
MOCA is more effective than the Mini-Mental State Examination at detecting cognitive dysfunction.
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- Using Telemedicine in Rheumatology: Outcomes, Costs, and Patient Satisfaction
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- Managing Bisphosphonate Drug Holidays in Patients With Osteoporosis
- BLA Submitted for Biosimilar Candidate to Remicade
- Social Support Protective Against Depression in African-American Women With SLE
- Vitamin D Deficiency Linked to Uveitis, Disease Activity in Juvenile Idiopathic Arthritis
- Synovial Thickening on Ultrasonography May Predict Arthritis Development
- Gender-Stratified Disease Activity Score Improves Inter-Score Agreement in RA
- FDA to Resume Inspections of Riskier Foods