Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have ...

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus

Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations.

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing ...

Identifying SLE-Related Health Demands Using Data Mining, Big Data

"Infodemiology" and "infoveillance" are terms used to describe an emerging approach to public health research, based on Google Trends big data monitoring and data mining.

Unmet Needs in the Pathogenesis, Treatment of Systemic Lupus Erythematosus

Improved survival has ushered in new challenges that inadvertently increase the risk for death in patients with SLE.

Cardiovascular Disease Risk in Patients With Systemic Lupus Erythematosus

Improved treatment in SLE with increased life expectancy has been accompanied by an elevated risk for developing cardiovascular diseases.

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Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions

Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions

Patients with early SLE had higher rates of unexplained fever than those with SLE-mimicking conditions.

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

Lupus nephritis in combination with impaired renal function is strongly associated with the presence of atherosclerosis in patients with systemic lupus erythematosus.

Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency

Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency

Researchers investigated the characteristics and outcomes of patients with systemic lupus erythematosus-associated thrombotic microangiopathy based on their ADAMTS13 inhibitor profiles.

Promising Antibody Markers Identified for aPL-Related Pregnancy Complications

Promising Antibody Markers Identified for aPL-Related Pregnancy Complications

The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, such as intrauterine grown restriction and preeclampsia.

High Risk for Zoster in Cyclophosphamide-Treated SLE, Systemic Vasculitis

High Risk for Zoster in Cyclophosphamide-Treated SLE, Systemic Vasculitis

The incidence of zoster is high in systemic vasculitis and in patients with SLE exposed to intravenous cyclophosphamide.

Epidemiology, Clinical Characteristics of Systemic Sclerosis vs SSc-SLE Overlap Syndrome

Epidemiology, Clinical Characteristics of Systemic Sclerosis vs SSc-SLE Overlap Syndrome

Patients with SSc-SLE overlap syndrome were younger at diagnosis, had higher rates of pulmonary arterial hypertension, and less frequently had SSc cutaneous manifestations.

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

The risk for depression was increased significantly in patients with systemic lupus erythematosus and cutaneous lupus erythematosus.

Silent Cardiac Impairment May Be Present in New-Onset, Drug-Naive Systemic Lupus Erythematosus

Silent Cardiac Impairment May Be Present in New-Onset, Drug-Naive Systemic Lupus Erythematosus

Data indicate that drug-naive new onset systemic lupus erythematosus was likely to involve silent cardiac impairment.

Poor Preconceptional Cardiovascular Health Affects Pregnancy Outcomes in SLE

Poor Preconceptional Cardiovascular Health Affects Pregnancy Outcomes in SLE

Poor preconception cardiovascular health affects pregnancy outcomes in women with SLE.

Burden of Entheseal Sonographic Changes High in Patients With SLE

Burden of Entheseal Sonographic Changes High in Patients With SLE

The burden of entheseal sonographic changes was significantly higher in patients with SLE vs healthy participants, especially with respect to active inflammation.

Corticosteroid Use Linked to Risk for Osteonecrosis in Systemic Lupus Erythematosus

Corticosteroid Use Linked to Risk for Osteonecrosis in Systemic Lupus Erythematosus

Investigators sought to identify the risk factors for osteonecrosis and to identify the minimal investigations needed to monitor the risk for osteonecrosis in patients with systemic lupus erythematosus.

Examining the Prevalence, Characteristics of Monophasic Disease Course in SLE

Examining the Prevalence, Characteristics of Monophasic Disease Course in SLE

Researchers sought to assess the prevalence and characteristics of monophasic disease course in a defined cohort of patients with SLE.

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

Routinely available serologic markers have no correlation with tubulointerstitial damage in patients with lupus nephritis.

Erythrocyte-Bound C4d May Be Useful for SLE Disease Monitoring

Erythrocyte-Bound C4d May Be Useful for SLE Disease Monitoring

Erythrocyte-bound C4d may be useful in monitoring systemic lupus erythematosus.

Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus

Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus

Outcomes in systemic lupus erythematosus are largely influenced by level of poverty, type of neighborhood of residence, and chronic stress.

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

Investigators sought to evaluate changes in demographic, clinical, and histologic presentation in patients with lupus nephritis between 1970 and 2016.

Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE

Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE

Female patients with systemic lupus erythematosus who had musculoskeletal symptoms or positive antiphospholipid antibodies demonstrated higher titers of anti-double-stranded DNA antibodies.

Increased Arterial Stiffness Observed in Patients With Systemic Lupus Erythematosus

Increased Arterial Stiffness Observed in Patients With Systemic Lupus Erythematosus

Patients with systemic lupus erythematosus exhibit increased central arterial stiffness compared with a healthy control population.

Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression

Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression

The relationship between pain and cognitive dysfunction was explained by sleep disturbance and depressive symptoms.

Bisphosphonate, Vitamin D Combination Therapy May Prevent Atherosclerosis in SLE

Bisphosphonate, Vitamin D Combination Therapy May Prevent Atherosclerosis in SLE

Bisphosphonates and vitamin D may help prevent atherosclerosis in patients with systemic lupus erythematosus.

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