Improving Medication Adherence With Drug Monitoring in SLE

Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE.

Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?

The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results.

Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have ...

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus

Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations.

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing ...

Identifying SLE-Related Health Demands Using Data Mining, Big Data

"Infodemiology" and "infoveillance" are terms used to describe an emerging approach to public health research, based on Google Trends big data monitoring and data mining.

Latest News

Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus

Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus

Results from a phase 2 study suggest that ustekinumab might be an effective therapy in systemic lupus erythematosus.

Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE

Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE

Patients with systemic lupus erythematosus have a high risk for postoperative complications and mortality following major surgery compared with patients without SLE.

Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus

Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus

Patient-reported outcomes are independent predictors of mortality in systemic lupus erythematosus.

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-onset SLE has major effects on quality of life in adulthood.

Active SLE Disease Activity, Damage Linked to Greater Mortality

Active SLE Disease Activity, Damage Linked to Greater Mortality

The use of validated disease activity and damage metrics is important in the assessment of SLE.

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

Cigarette smoking was associated with an increased SLE risk and alcohol consumption was associated with decreased SLE risk.

Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE

Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE

Prolonged antimalarial therapy and persistent creatine phosphokinase elevation resulted in an increased risk for abnormal brain natriuretic peptide and cardiac troponin.

High Rate of Subclinical Myocardial Injury in Systemic Lupus Erythematosus

High Rate of Subclinical Myocardial Injury in Systemic Lupus Erythematosus

Patients with systemic lupus erythematosus have a high prevalence of subclinical myocardial injury, as evidenced by raised high-sensitive troponin levels.

Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions

Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions

Patients with early SLE had higher rates of unexplained fever than those with SLE-mimicking conditions.

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

Lupus nephritis in combination with impaired renal function is strongly associated with the presence of atherosclerosis in patients with systemic lupus erythematosus.

Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency

Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency

Researchers investigated the characteristics and outcomes of patients with systemic lupus erythematosus-associated thrombotic microangiopathy based on their ADAMTS13 inhibitor profiles.

Promising Antibody Markers Identified for aPL-Related Pregnancy Complications

Promising Antibody Markers Identified for aPL-Related Pregnancy Complications

The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, such as intrauterine grown restriction and preeclampsia.

High Risk for Zoster in Cyclophosphamide-Treated SLE, Systemic Vasculitis

High Risk for Zoster in Cyclophosphamide-Treated SLE, Systemic Vasculitis

The incidence of zoster is high in systemic vasculitis and in patients with SLE exposed to intravenous cyclophosphamide.

Epidemiology, Clinical Characteristics of Systemic Sclerosis vs SSc-SLE Overlap Syndrome

Epidemiology, Clinical Characteristics of Systemic Sclerosis vs SSc-SLE Overlap Syndrome

Patients with SSc-SLE overlap syndrome were younger at diagnosis, had higher rates of pulmonary arterial hypertension, and less frequently had SSc cutaneous manifestations.

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

The risk for depression was increased significantly in patients with systemic lupus erythematosus and cutaneous lupus erythematosus.

Silent Cardiac Impairment May Be Present in New-Onset, Drug-Naive Systemic Lupus Erythematosus

Silent Cardiac Impairment May Be Present in New-Onset, Drug-Naive Systemic Lupus Erythematosus

Data indicate that drug-naive new onset systemic lupus erythematosus was likely to involve silent cardiac impairment.

Poor Preconceptional Cardiovascular Health Affects Pregnancy Outcomes in SLE

Poor Preconceptional Cardiovascular Health Affects Pregnancy Outcomes in SLE

Poor preconception cardiovascular health affects pregnancy outcomes in women with SLE.

Burden of Entheseal Sonographic Changes High in Patients With SLE

Burden of Entheseal Sonographic Changes High in Patients With SLE

The burden of entheseal sonographic changes was significantly higher in patients with SLE vs healthy participants, especially with respect to active inflammation.

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