The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome

Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut.

Improving Medication Adherence With Drug Monitoring in SLE

Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE.

Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?

The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results.

Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have ...

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus

Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations.

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing ...

Latest News

Social Support Protective Against Depression in African-American Women With SLE

Social Support Protective Against Depression in African-American Women With SLE

Organ damage was positively correlated with depression in women with systemic lupus erythematosus, while social support offered protection against depression.

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

Using electrochemiluminescence, researchers found 5 urinary proteins that have "reasonable specificity" for lupus nephritis.

Antiphospholipid Score Validated as Risk Factor for Idiopathic Osteonecrosis of the Femoral Head in SLE

Antiphospholipid Score Validated as Risk Factor for Idiopathic Osteonecrosis of the Femoral Head in SLE

Researchers identified a high antiphospholipid score as a novel risk factor for idiopathic osteonecrosis of the femoral head in patients with systemic lupus erythematosus.

SLE Remission Strongly Linked to Improved Quality of Life

SLE Remission Strongly Linked to Improved Quality of Life

Disease remission is associated with an improved physical domains of health-related quality of life in patients with systemic lupus erythematosus.

Promising Screening Tools Assessed for Cognitive Dysfunction in Systemic Lupus Erythematosus

Promising Screening Tools Assessed for Cognitive Dysfunction in Systemic Lupus Erythematosus

Researchers evaluated the Montreal Cognitive Assessment questionnaire and the Informant Questionnaire on Cognitive Decline in the Elderly as screening tools for cognitive dysfunction in SLE.

Baricitinib Gets Fast Track Status for Systemic Lupus Erythematosus

Baricitinib Gets Fast Track Status for Systemic Lupus Erythematosus

Data from a phase 2 trial of baricitinib for the treatment of SLE supporting the Fast Track designation were published in The Lancet and presented at the European Congress of Rheumatology earlier this year.

Antimalarial-Induced Cardiomyopathy May Be Underrecognized in Systemic Lupus Erythematosus

Antimalarial-Induced Cardiomyopathy May Be Underrecognized in Systemic Lupus Erythematosus

Researchers described 8 patients with antimalarial-induced cardiomyopathy in a defined systemic lupus erythematosus cohort.

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

Researchers observed comparable long-term outcomes between patients with late- and early-onset lupus nephritis.

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Data support the clinical efficacy of low-dose leflunomide combined with prednisone for the treatment of proliferative lupus nephritis.

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

Intrauterine fetal death may be an early sign of antiphospholipid syndrome in pregnant women.

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

Risk factors for psychosis in SLE included male sex and African ancestry.

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

Researchers examined the role of CB-CAPs for diagnosis and monitoring of pediatric-onset SLE.

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

Investigators evaluated the immunogenicity of pneumococcal vaccination in children with systemic lupus erythematosus.

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

A positive direct Coombs test in the absence of hemolytic anemia may be a useful biomarker for assessing disease activity in systemic lupus erythematosus.

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

High and low HCQ levels were associated with preterm birth and disease activity in SLE.

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

Long-term treatment of SLE with belimumab with standard of care resulted in sustained benefits in patient fatigue and health-related quality of life.

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

A strong association between antiphospholipid positivity and first-time MI may represent a risk factor for myocardial infarction.

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

Investigators sought to define the clinical association of clinical and imaging definitions of synovitis in patients with SLE with musculoskeletal symptoms.

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

Researchers identified SERPINA3 as a potential urine biomarker to quantify lupus nephritis.

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

Researchers sought to determine whether a cardiovascular magnetic resonance protocol may be useful for early diagnosis of heart disease in patients with systemic lupus erythematosus.

Sign Up for Free e-newsletters