The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome

Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut.

Improving Medication Adherence With Drug Monitoring in SLE

Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE.

Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?

The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results.

Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have ...

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus

Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations.

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing ...

Latest News

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Data support the clinical efficacy of low-dose leflunomide combined with prednisone for the treatment of proliferative lupus nephritis.

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

Intrauterine fetal death may be an early sign of antiphospholipid syndrome in pregnant women.

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

Risk factors for psychosis in SLE included male sex and African ancestry.

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

Researchers examined the role of CB-CAPs for diagnosis and monitoring of pediatric-onset SLE.

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

Investigators evaluated the immunogenicity of pneumococcal vaccination in children with systemic lupus erythematosus.

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

A positive direct Coombs test in the absence of hemolytic anemia may be a useful biomarker for assessing disease activity in systemic lupus erythematosus.

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

High and low HCQ levels were associated with preterm birth and disease activity in SLE.

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

Long-term treatment of SLE with belimumab with standard of care resulted in sustained benefits in patient fatigue and health-related quality of life.

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

A strong association between antiphospholipid positivity and first-time MI may represent a risk factor for myocardial infarction.

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

Investigators sought to define the clinical association of clinical and imaging definitions of synovitis in patients with SLE with musculoskeletal symptoms.

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

Researchers identified SERPINA3 as a potential urine biomarker to quantify lupus nephritis.

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

Researchers sought to determine whether a cardiovascular magnetic resonance protocol may be useful for early diagnosis of heart disease in patients with systemic lupus erythematosus.

Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus

Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus

Results from a phase 2 study suggest that ustekinumab might be an effective therapy in systemic lupus erythematosus.

Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE

Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE

Patients with systemic lupus erythematosus have a high risk for postoperative complications and mortality following major surgery compared with patients without SLE.

Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus

Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus

Patient-reported outcomes are independent predictors of mortality in systemic lupus erythematosus.

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-onset SLE has major effects on quality of life in adulthood.

Active SLE Disease Activity, Damage Linked to Greater Mortality

Active SLE Disease Activity, Damage Linked to Greater Mortality

The use of validated disease activity and damage metrics is important in the assessment of SLE.

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

Cigarette smoking was associated with an increased SLE risk and alcohol consumption was associated with decreased SLE risk.

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