Systemic Lupus Erythematosus

Predicting Treatment Success in Systemic Lupus Erythematosus-Associated PAH

Predicting Treatment Success in Systemic Lupus Erythematosus-Associated PAH

By

Treatment success in systemic lupus erythematosus-associated pulmonary arterial hypertension, as defined by the European Society of Cardiology and the European Respiratory Society, is associated with long-term survival and supports a treat-to-target strategy.

Hepatitis A Vaccine Safe in Childhood-Onset SLE

Hepatitis A Vaccine Safe in Childhood-Onset SLE

By

Inactivated hepatitis A vaccine may be safe and well tolerated in childhood-onset systemic lupus erythematosus.

Case Study: Systemic Lupus Erythematosus With Lupus Nephritis and Thrombotic Microangiopathy

Case Study: Systemic Lupus Erythematosus With Lupus Nephritis and Thrombotic Microangiopathy

A 19-year-old woman presents with complaints of progressive shortness of breath, chest pain, and lower extremity edema over the past month.

Omalizumab Safe, Well-Tolerated in Mild to Moderate Systemic Lupus Erythematosus

Omalizumab Safe, Well-Tolerated in Mild to Moderate Systemic Lupus Erythematosus

By

Omalizumab was well tolerated in patients with systemic lupus erythematosus, and was associated with improvement in disease activity.

Lupus Nephritis Therapy Response Predicts Survival Odds

Lupus Nephritis Therapy Response Predicts Survival Odds

By

Complete response to induction therapy is associated with significant 82% decreased odds of death at 12 months.

Novel Disease Activity Tool Validated to Detect Changes in SLE

Novel Disease Activity Tool Validated to Detect Changes in SLE

By

Researchers validated the SLE Disease Activity Score with improved sensitivity to change compared with SLE Disease Activity Index.

Kidney Transplantation Increases Survival in Lupus Nephritis Cases

Kidney Transplantation Increases Survival in Lupus Nephritis Cases

By

In a nationwide study, renal transplant recipients with lupus nephritis had a 70% lower risk for all-cause mortality than nonrecipients.

Belimumab May Reduce Organ Damage Progression in Systemic Lupus Erythematosus

Belimumab May Reduce Organ Damage Progression in Systemic Lupus Erythematosus

By

Belimumab with standard of care treatment resulted in lower rates of organ damage accrual compared with standard of care alone.

Clinical Trials in Childhood-Onset Systemic Lupus Erythematosus: Next Steps and Future Directions

Clinical Trials in Childhood-Onset Systemic Lupus Erythematosus: Next Steps and Future Directions

By

Access to medications for childhood-onset systemic lupus erythematosus is currently limited, partly because of a lack of high-quality evidence from clinical trials.

IgG Autoantibody Profile Examined in Established Systemic Lupus Erythematosus

IgG Autoantibody Profile Examined in Established Systemic Lupus Erythematosus

By

Researchers examined the role of epitope spreading in established systemic lupus erythematosus.

Social Support Protective Against Depression in African-American Women With SLE

Social Support Protective Against Depression in African-American Women With SLE

By

Organ damage was positively correlated with depression in women with systemic lupus erythematosus, while social support offered protection against depression.

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

By

Using electrochemiluminescence, researchers found 5 urinary proteins that have "reasonable specificity" for lupus nephritis.

Antiphospholipid Score Validated as Risk Factor for Idiopathic Osteonecrosis of the Femoral Head in SLE

Antiphospholipid Score Validated as Risk Factor for Idiopathic Osteonecrosis of the Femoral Head in SLE

By

Researchers identified a high antiphospholipid score as a novel risk factor for idiopathic osteonecrosis of the femoral head in patients with systemic lupus erythematosus.

SLE Remission Strongly Linked to Improved Quality of Life

SLE Remission Strongly Linked to Improved Quality of Life

By

Disease remission is associated with an improved physical domains of health-related quality of life in patients with systemic lupus erythematosus.

Promising Screening Tools Assessed for Cognitive Dysfunction in Systemic Lupus Erythematosus

Promising Screening Tools Assessed for Cognitive Dysfunction in Systemic Lupus Erythematosus

By

Researchers evaluated the Montreal Cognitive Assessment questionnaire and the Informant Questionnaire on Cognitive Decline in the Elderly as screening tools for cognitive dysfunction in SLE.

Baricitinib Gets Fast Track Status for Systemic Lupus Erythematosus

Baricitinib Gets Fast Track Status for Systemic Lupus Erythematosus

By

Data from a phase 2 trial of baricitinib for the treatment of SLE supporting the Fast Track designation were published in The Lancet and presented at the European Congress of Rheumatology earlier this year.

Antimalarial-Induced Cardiomyopathy May Be Underrecognized in Systemic Lupus Erythematosus

Antimalarial-Induced Cardiomyopathy May Be Underrecognized in Systemic Lupus Erythematosus

By

Researchers described 8 patients with antimalarial-induced cardiomyopathy in a defined systemic lupus erythematosus cohort.

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

By

Researchers observed comparable long-term outcomes between patients with late- and early-onset lupus nephritis.

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

By

Data support the clinical efficacy of low-dose leflunomide combined with prednisone for the treatment of proliferative lupus nephritis.

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

By

Intrauterine fetal death may be an early sign of antiphospholipid syndrome in pregnant women.

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

By

Risk factors for psychosis in SLE included male sex and African ancestry.

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

By

Researchers examined the role of CB-CAPs for diagnosis and monitoring of pediatric-onset SLE.

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

By

Investigators evaluated the immunogenicity of pneumococcal vaccination in children with systemic lupus erythematosus.

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

By

A positive direct Coombs test in the absence of hemolytic anemia may be a useful biomarker for assessing disease activity in systemic lupus erythematosus.

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

By

High and low HCQ levels were associated with preterm birth and disease activity in SLE.

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

By

Long-term treatment of SLE with belimumab with standard of care resulted in sustained benefits in patient fatigue and health-related quality of life.

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

By

A strong association between antiphospholipid positivity and first-time MI may represent a risk factor for myocardial infarction.

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

By

Investigators sought to define the clinical association of clinical and imaging definitions of synovitis in patients with SLE with musculoskeletal symptoms.

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

By

Researchers identified SERPINA3 as a potential urine biomarker to quantify lupus nephritis.

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

By

Researchers sought to determine whether a cardiovascular magnetic resonance protocol may be useful for early diagnosis of heart disease in patients with systemic lupus erythematosus.

Sign Up for Free e-newsletters