Systemic Lupus Erythematosus
Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus
June 18, 2018Outcomes in systemic lupus erythematosus are largely influenced by level of poverty, type of neighborhood of residence, and chronic stress.
SLE-DAS Superior to SLEDAI-2K in Detecting Changes in SLE Disease Activity
June 15, 2018To assess validity of SLE-DAS, investigators performed a Spearman's correlation between SLE-DAS, PGA, and SLEDAI-2K at the last follow-up visit.
Cardiac Screening May Not Be Beneficial in SLE With Anti-Ro Antibodies
June 14, 2018Cardiac screening in patients with systemic lupus erythematosus and anti-Ro-positive antibodies does not appear to be beneficial in clinical practice.
Baricitinib Shows Positive Results for Systemic Lupus Erythematosus in Phase 2 Study
June 13, 2018Baricitinib 4 mg was safe and effective in patients with systemic lupus erythematosus.
Determining Elevated Thrombotic Risk in Systemic Lupus Erythematosus
June 13, 2018Recent data from EULAR 2018 highlight the existence of thrombotic factors in systemic lupus erythematosus.
Obesity May Not Be Associated With Development of Lupus Nephritis
June 13, 2018Obesity is not associated with the development of lupus nephritis among patients with systemic lupus erythematosus.
Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis
June 07, 2018Investigators sought to evaluate changes in demographic, clinical, and histologic presentation in patients with lupus nephritis between 1970 and 2016.
Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE
June 06, 2018Female patients with systemic lupus erythematosus who had musculoskeletal symptoms or positive antiphospholipid antibodies demonstrated higher titers of anti-double-stranded DNA antibodies.
Managing Cognitive Dysfunction in Systemic Lupus Erythematosus
May 31, 2018The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have been proposed as contributing factors.
PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE
May 31, 2018Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.
Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus
May 24, 2018Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations.
Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression
May 22, 2018The relationship between pain and cognitive dysfunction was explained by sleep disturbance and depressive symptoms.
Bisphosphonate, Vitamin D Combination Therapy May Prevent Atherosclerosis in SLE
May 21, 2018Bisphosphonates and vitamin D may help prevent atherosclerosis in patients with systemic lupus erythematosus.
ACR Provisional Criteria: Global Flares in Childhood-Onset SLE
May 15, 2018Provisional criteria for global flares in patients with childhood-onset systemic lupus erythematosus are now available from the ACR.
Effects of SLE Diagnosis Examined in Antiphospholipid Antibody-Positive Patients
May 10, 2018Researchers compared the clinical, laboratory, and treatment characteristics of antiphospholipid antibody-positive patients with or without SLE.
Repeat Antibody Testing May Be Unnecessary for Some Patients With SLE
May 09, 2018Data show that anti-ENA results change infrequently, especially following 1 or more negative tests.
Case Report: Nephrotic Syndrome and Chronic HCV in a 72-Year-Old Woman
May 04, 2018A 72-year-old Japanese woman with a 40-year history of lupus nephritis presented with leg edema that had lasted for several weeks.
Belimumab Effective for Hypocomplementemic, Anti-dsDNA-Positive SLE
May 03, 2018Weekly belimumab treatment was safe and effective and superior to placebo for reducing disease activity over 52 weeks in patients who were hypocomplementemic and anti-dsDNA positive.
Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes
May 02, 2018Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.
Incident Proteinuria in SLE May Be Predicted by Certain Clinical, Serological Manifestations
May 01, 2018Certain clinical and serological markers were predictive of future incident proteinuria in patients with systemic lupus erythematosus.
Lupus Is a Leading Cause of Death in Young Women
April 26, 2018Systemic lupus erythematosus is among the top 20 leading causes of death in women between the ages of 5 and 64 years in the United States.
Identifying Social Determinants of Mortality in Systemic Lupus Erythematosus
April 25, 2018Investigators suggest several mechanisms for the contribution of poverty to high mortality rates in patients with systemic lupus erythematosus.
Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic
April 20, 2018Researchers compared the quality of care received by patients with systemic lupus erythematosus in 2 settings within the same academic institution.
Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes
April 20, 2018Judith A. James, MD, PhD, discusses the developments of precision medicine in rheumatology at the 2018 State-of-the-Art Clinical Symposium.
Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA
April 17, 2018The Epstein-Barr virus EBNA2 protein and many coclustering human transcription factors occupied nearly half of SLE risk loci.
Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus
April 11, 2018The frequency of metabolic syndrome among patients with SLE was approximately 45%.
Efficacy of Blisibimod Therapy Evaluated in Systemic Lupus Erythematosus
April 10, 2018Blisibimod was effective in patients with SLE in terms of steroid reduction, decreased proteinuria, and improvement in serological markers.
Ubiquitination in NETs May Affect Adaptive Immune Responses in SLE
April 09, 2018Neutrophil extracellular traps contain ubiquitinated proteins with a lower expression of polyubiquitinated proteins in patients with SLE.
Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis
April 05, 2018Researchers examined differences in the ability to get pregnant in women with systemic lupus erythematosus and rheumatoid arthritis.
Ofatumumab Safe, Effective for B Cell Depletion in Rituximab-Intolerant SLE
April 02, 2018Ofatumumab was a well-tolerated, safe, and effective alternative to rituximab for B cell depletion therapy.
Rheumatology Advisor Articles
- Baricitinib Shows Positive Results for Systemic Lupus Erythematosus in Phase 2 Study
- Bimekizumab Linked to 12-Week Clinical Improvements in Ankylosing Spondylitis
- Tofacitinib May Effectively Alleviate Pain in RA, Psoriatic Arthritis, and Ankylosing Spondylitis
- Sprifermin Improved Cartilage Morphology, Thickness in Knee Osteoarthritis
- Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus
- Examining the Therapeutic Possibilities of Nutrition in Fibromyalgia
- Managing Cognitive Dysfunction in Systemic Lupus Erythematosus
- Sex-Based Differences in Rheumatoid Arthritis: Clinical Implications and Patient Management
- False-Positive Tuberculin Skin Test Results Linked to Methotrexate Therapy
- Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus
- Addressing Confidentiality Concerns With Electronic Access to Pediatric Medical Records
- Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women
- Multisystem Intervention Reduces Missed Opportunities for Influenza Vaccination in RA
- How Is Attending Physician Supervision Linked to Resident, Intern Medical Error Rate?
- PAH in Systemic Sclerosis Increases Risk for Early Mortality