Systemic Lupus Erythematosus
Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis
November 29, 2018Data support the clinical efficacy of low-dose leflunomide combined with prednisone for the treatment of proliferative lupus nephritis.
Intrauterine Fetal Death Associated With Antiphospholipid Syndrome
November 27, 2018Intrauterine fetal death may be an early sign of antiphospholipid syndrome in pregnant women.
Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable
November 27, 2018Risk factors for psychosis in SLE included male sex and African ancestry.
Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis
November 26, 2018Researchers examined the role of CB-CAPs for diagnosis and monitoring of pediatric-onset SLE.
Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE
November 21, 2018Investigators evaluated the immunogenicity of pneumococcal vaccination in children with systemic lupus erythematosus.
Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE
November 21, 2018A positive direct Coombs test in the absence of hemolytic anemia may be a useful biomarker for assessing disease activity in systemic lupus erythematosus.
High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE
November 13, 2018High and low HCQ levels were associated with preterm birth and disease activity in SLE.
Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE
November 05, 2018Long-term treatment of SLE with belimumab with standard of care resulted in sustained benefits in patient fatigue and health-related quality of life.
Strong Association Found Between Antiphospholipid Antibodies and First-Time MI
November 05, 2018A strong association between antiphospholipid positivity and first-time MI may represent a risk factor for myocardial infarction.
Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus
November 02, 2018Investigators sought to define the clinical association of clinical and imaging definitions of synovitis in patients with SLE with musculoskeletal symptoms.
SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity
November 01, 2018Researchers identified SERPINA3 as a potential urine biomarker to quantify lupus nephritis.
Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE
October 31, 2018Researchers sought to determine whether a cardiovascular magnetic resonance protocol may be useful for early diagnosis of heart disease in patients with systemic lupus erythematosus.
The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome
October 31, 2018Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut.
Opioid Use High in Patients With Systemic Lupus Erythematosus
October 24, 2018Patients with SLE who experienced high pain levels and had a visit to the emergency department the previous year were more likely to use opioids.
ACR/ARHP 2018: Researchers Debate Hydroxychloroquine Dosing in SLE
October 23, 2018Experts at the 2018 ACR/ARHP Annual Meeting discuss whether hydroxychloroquine dosing should be more than 5 mg/kg in patients with systemic lupus erythematosus.
Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus
October 11, 2018Results from a phase 2 study suggest that ustekinumab might be an effective therapy in systemic lupus erythematosus.
Improving Medication Adherence With Drug Monitoring in SLE
October 05, 2018Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE.
Rheumatic Disease Risk Increased in Myasthenia Gravis After Thymectomy
October 03, 2018Data revealed an association between myasthenia gravis and autoimmune rheumatic diseases.
Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE
October 01, 2018Patients with systemic lupus erythematosus have a high risk for postoperative complications and mortality following major surgery compared with patients without SLE.
Statin Initiation Reduces Overall Mortality in Systemic Autoimmune Rheumatic Diseases
September 24, 2018The initiation of statin therapy is associated with reduced overall mortality in patients with systemic autoimmune rheumatic diseases.
Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus
September 24, 2018Patient-reported outcomes are independent predictors of mortality in systemic lupus erythematosus.
Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE
September 21, 2018Vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.
Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis
September 19, 2018Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.
Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood
September 17, 2018Childhood-onset SLE has major effects on quality of life in adulthood.
Active SLE Disease Activity, Damage Linked to Greater Mortality
September 04, 2018The use of validated disease activity and damage metrics is important in the assessment of SLE.
Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women
August 31, 2018Cigarette smoking was associated with an increased SLE risk and alcohol consumption was associated with decreased SLE risk.
Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE
August 29, 2018Prolonged antimalarial therapy and persistent creatine phosphokinase elevation resulted in an increased risk for abnormal brain natriuretic peptide and cardiac troponin.
Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?
August 28, 2018The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results.
High Rate of Subclinical Myocardial Injury in Systemic Lupus Erythematosus
August 27, 2018Patients with systemic lupus erythematosus have a high prevalence of subclinical myocardial injury, as evidenced by raised high-sensitive troponin levels.
Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions
August 15, 2018Patients with early SLE had higher rates of unexplained fever than those with SLE-mimicking conditions.
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