Systemic Lupus Erythematosus

Baricitinib Gets Fast Track Status for Systemic Lupus Erythematosus

Baricitinib Gets Fast Track Status for Systemic Lupus Erythematosus

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Data from a Phase 2 trial of baricitinib for the treatment of SLE supporting the Fast Track designation were published in The Lancet and presented at the European Congress of Rheumatology earlier this year.

Antimalarial-Induced Cardiomyopathy May Be Underrecognized in Systemic Lupus Erythematosus

Antimalarial-Induced Cardiomyopathy May Be Underrecognized in Systemic Lupus Erythematosus

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Researchers described 8 patients with antimalarial-induced cardiomyopathy in a defined systemic lupus erythematosus cohort.

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

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Researchers observed comparable long-term outcomes between patients with late- and early-onset lupus nephritis.

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

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Data support the clinical efficacy of low-dose leflunomide combined with prednisone for the treatment of proliferative lupus nephritis.

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

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Intrauterine fetal death may be an early sign of antiphospholipid syndrome in pregnant women.

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

Psychosis in Systemic Lupus Erythematosus Is Rare, Manageable

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Risk factors for psychosis in SLE included male sex and African ancestry.

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

Cell-Bound Complement Activation Products May Help Pediatric-Onset SLE Diagnosis

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Researchers examined the role of CB-CAPs for diagnosis and monitoring of pediatric-onset SLE.

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

Immunogenicity of Pneumococcal Vaccines Examined in Children With SLE

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Investigators evaluated the immunogenicity of pneumococcal vaccination in children with systemic lupus erythematosus.

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

Positive Coombs Test Without Hemolytic Anemia Predicts Disease Activity in SLE

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A positive direct Coombs test in the absence of hemolytic anemia may be a useful biomarker for assessing disease activity in systemic lupus erythematosus.

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

High and Low HCQ Levels During Pregnancy Linked to Preterm Birth, Disease Activity in SLE

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High and low HCQ levels were associated with preterm birth and disease activity in SLE.

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

Long-Term Belimumab Treatment Improves Fatigue, Quality of Life in SLE

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Long-term treatment of SLE with belimumab with standard of care resulted in sustained benefits in patient fatigue and health-related quality of life.

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

Strong Association Found Between Antiphospholipid Antibodies and First-Time MI

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A strong association between antiphospholipid positivity and first-time MI may represent a risk factor for myocardial infarction.

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

Identifying Musculoskeletal Manifestations in Systemic Lupus Erythematosus

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Investigators sought to define the clinical association of clinical and imaging definitions of synovitis in patients with SLE with musculoskeletal symptoms.

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

SERPINA3 Identified as Candidate Urinary Biomarker for Lupus Nephritis Activity

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Researchers identified SERPINA3 as a potential urine biomarker to quantify lupus nephritis.

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

Cardiovascular Magnetic Resonance Tomography May Detect Cardiac Complications in SLE

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Researchers sought to determine whether a cardiovascular magnetic resonance protocol may be useful for early diagnosis of heart disease in patients with systemic lupus erythematosus.

The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome

The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome

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Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut.

Opioid Use High in Patients With Systemic Lupus Erythematosus

Opioid Use High in Patients With Systemic Lupus Erythematosus

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Patients with SLE who experienced high pain levels and had a visit to the emergency department the previous year were more likely to use opioids.

ACR/ARHP 2018: Researchers Debate Hydroxychloroquine Dosing in SLE

ACR/ARHP 2018: Researchers Debate Hydroxychloroquine Dosing in SLE

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Experts at the 2018 ACR/ARHP Annual Meeting discuss whether hydroxychloroquine dosing should be more than 5 mg/kg in patients with systemic lupus erythematosus.

Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus

Ustekinumab Effective in Phase 2 Study for Systemic Lupus Erythematosus

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Results from a phase 2 study suggest that ustekinumab might be an effective therapy in systemic lupus erythematosus.

Improving Medication Adherence With Drug Monitoring in SLE

Improving Medication Adherence With Drug Monitoring in SLE

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Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE.

Rheumatic Disease Risk Increased in Myasthenia Gravis After Thymectomy

Rheumatic Disease Risk Increased in Myasthenia Gravis After Thymectomy

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Data revealed an association between myasthenia gravis and autoimmune rheumatic diseases.

Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE

Infectious, Noninfectious Postoperative Complications More Frequent in Patients With SLE

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Patients with systemic lupus erythematosus have a high risk for postoperative complications and mortality following major surgery compared with patients without SLE.

Statin Initiation Reduces Overall Mortality in Systemic Autoimmune Rheumatic Diseases

Statin Initiation Reduces Overall Mortality in Systemic Autoimmune Rheumatic Diseases

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The initiation of statin therapy is associated with reduced overall mortality in patients with systemic autoimmune rheumatic diseases.

Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus

Patient-Reported Outcomes Predict Mortality in Systemic Lupus Erythematosus

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Patient-reported outcomes are independent predictors of mortality in systemic lupus erythematosus.

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

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Vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

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Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

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Childhood-onset SLE has major effects on quality of life in adulthood.

 Active SLE Disease Activity, Damage Linked to Greater Mortality

Active SLE Disease Activity, Damage Linked to Greater Mortality

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The use of validated disease activity and damage metrics is important in the assessment of SLE.

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

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Cigarette smoking was associated with an increased SLE risk and alcohol consumption was associated with decreased SLE risk.

Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE

Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE

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Prolonged antimalarial therapy and persistent creatine phosphokinase elevation resulted in an increased risk for abnormal brain natriuretic peptide and cardiac troponin.

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