Systemic Lupus Erythematosus

Lupus Is a Leading Cause of Death in Young Women

Lupus Is a Leading Cause of Death in Young Women

Systemic lupus erythematosus is among the top 20 leading causes of death in women between the ages of 5 and 64 years in the United States.

Identifying Social Determinants of Mortality in Systemic Lupus Erythematosus

Identifying Social Determinants of Mortality in Systemic Lupus Erythematosus

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Investigators suggest several mechanisms for the contribution of poverty to high mortality rates in patients with systemic lupus erythematosus.

Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic

Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic

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Researchers compared the quality of care received by patients with systemic lupus erythematosus in 2 settings within the same academic institution.

Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes

Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes

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Judith A. James, MD, PhD, discusses the developments of precision medicine in rheumatology at the 2018 State-of-the-Art Clinical Symposium.

Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA

Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA

The Epstein-Barr virus EBNA2 protein and many coclustering human transcription factors occupied nearly half of SLE risk loci.

Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus

Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus

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The frequency of metabolic syndrome among patients with SLE was approximately 45%.

Efficacy of Blisibimod Therapy Evaluated in Systemic Lupus Erythematosus

Efficacy of Blisibimod Therapy Evaluated in Systemic Lupus Erythematosus

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Blisibimod was effective in patients with SLE in terms of steroid reduction, decreased proteinuria, and improvement in serological markers.

Ubiquitination in NETs May Affect Adaptive Immune Responses in SLE

Ubiquitination in NETs May Affect Adaptive Immune Responses in SLE

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Neutrophil extracellular traps contain ubiquitinated proteins with a lower expression of polyubiquitinated proteins in patients with SLE.

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

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Researchers examined differences in the ability to get pregnant in women with systemic lupus erythematosus and rheumatoid arthritis.

Ofatumumab Safe, Effective for B Cell Depletion in Rituximab-Intolerant SLE

Ofatumumab Safe, Effective for B Cell Depletion in Rituximab-Intolerant SLE

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Ofatumumab was a well-tolerated, safe, and effective alternative to rituximab for B cell depletion therapy.

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

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Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

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The IL-19 risk allele is associated with stroke and myocardial infarction in patients with systemic lupus erythematosus and rheumatoid arthritis, but not in the general population.

Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

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Researchers investigated serum IgG anti-MDA expression and associations with disease activity in patients with systemic lupus erythematosus.

Examining Lupus Low Disease Activity State as an SLE Outcome Measure

Examining Lupus Low Disease Activity State as an SLE Outcome Measure

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Results from the MUSE trial show that lupus low disease activity state attainment in patients with systemic lupus erythematosus is a clinically meaningful disease outcome measure.

Higher Rate of Atrial Fibrillation in Men With Systemic Lupus Erythematosus

Higher Rate of Atrial Fibrillation in Men With Systemic Lupus Erythematosus

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Researchers used phenotype-wide association studies to uncover associations in men and women with systemic lupus erythematosus.

Systemic Lupus Erythematosus Disease Flares Increase During, Shortly After Pregnancy

Systemic Lupus Erythematosus Disease Flares Increase During, Shortly After Pregnancy

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Researchers found that disease flare incidence in women with SLE increased during pregnancy and within 3 months postpartum.

Mortality, ESRD Incidence Measured in Men vs Women With Lupus Nephritis

Mortality, ESRD Incidence Measured in Men vs Women With Lupus Nephritis

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No significant differences were observed in the incidence of ESRD and mortality among men vs women with lupus nephritis.

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

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Disease damage in patients with childhood-onset SLE is common, even with relatively short disease durations.

Epratuzumab in SLE With Associated Sjogren Syndrome Improved SLE Disease Activity

Epratuzumab in SLE With Associated Sjogren Syndrome Improved SLE Disease Activity

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Epratuzumab improved systemic lupus erythematosus disease activity in patients with associated Sjogren syndrome.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

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Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Few SLE Patients Receive Retinal Examinations With Hydroxychloroquine Initiation

Few SLE Patients Receive Retinal Examinations With Hydroxychloroquine Initiation

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Researchers examined the proportion of Medicaid patients with systemic lupus erythematosus who receive baseline retinal examinations when initiating treatment with hydroxychloroquine.

Raynaud Phenomenon, Migraine Linked to aPS/PT Antibodies in Primary Antiphospholipid Syndrome

Raynaud Phenomenon, Migraine Linked to aPS/PT Antibodies in Primary Antiphospholipid Syndrome

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In patients with primary antiphospholipid syndrome, the presence of phosphatidylserine/prothrombin complex antibodies is associated with Raynaud phenomenon and migraine.

Predictors of Disability Assessed in Childhood-Onset Systemic Lupus Erythematosus

Predictors of Disability Assessed in Childhood-Onset Systemic Lupus Erythematosus

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Data from the CARRA Legacy Registry show disability is common in patients with childhood-onset SLE.

Smoking Status Linked to Risk for Anti-Double Stranded DNA SLE Subtype

Smoking Status Linked to Risk for Anti-Double Stranded DNA SLE Subtype

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Smoking is associated with risk for development of the anti-double-stranded DNA positive subtype of systemic lupus erythematosus.

Comparable Risk for Atherosclerosis in Antiphospholipid Syndrome and Diabetes

Comparable Risk for Atherosclerosis in Antiphospholipid Syndrome and Diabetes

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Patients with primary antiphospholipid syndrome and systemic lupus erythematosus-associated antiphospholipid syndrome have an almost 2.5-fold risk for development of atherosclerotic plaques in carotid and femoral arteries compared with healthy control patients.

Predictors of Incident Proteinuria in Systemic Lupus Erythematosus

Predictors of Incident Proteinuria in Systemic Lupus Erythematosus

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Older patients with SLE are at a low risk for the development of proteinuria.

Failure to Achieve Low Disease Activity Linked to Early Damage Accrual in SLE

Failure to Achieve Low Disease Activity Linked to Early Damage Accrual in SLE

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Lupus low disease activity state has been shown to be achievable and negatively associated with early damage accrual.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal Lupus: Clinical Manifestations and Treatment Options

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Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing fetus.

Consistent Antimalarial Intake in First 5 Years of SLE Linked to Improved Prognosis

Consistent Antimalarial Intake in First 5 Years of SLE Linked to Improved Prognosis

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Investigators evaluated long-term outcomes with antimalarial use and organ damage, flares, disease activity, glucocorticoid use, and antimalarial associated retinopathy.

Identifying SLE-Related Health Demands Using Data Mining, Big Data

Identifying SLE-Related Health Demands Using Data Mining, Big Data

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"Infodemiology" and "infoveillance" are terms used to describe an emerging approach to public health research, based on Google Trends big data monitoring and data mining.

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