Systemic Sclerosis

Risk Factors for Scleroderma Renal Crisis in Systemic Sclerosis

Risk Factors for Scleroderma Renal Crisis in Systemic Sclerosis

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Researchers identify risk factors for scleroderma renal crisis in patients with systemic sclerosis.

Strong Reproducibility for 6-Minute Walk Test in Systemic Sclerosis

Strong Reproducibility for 6-Minute Walk Test in Systemic Sclerosis

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Investigators assessed the reproducibility and the utility of the 6-minute walk test in systemic sclerosis.

Little Data Available for Small Intestinal Bacterial Overgrowth Treatment in Systemic Sclerosis

Little Data Available for Small Intestinal Bacterial Overgrowth Treatment in Systemic Sclerosis

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For some patients with systemic sclerosis, antibiotics can eradicate small intestinal bacterial overgrowth.

SPAR Model May Predict Mild Interstitial Lung Disease in Systemic Sclerosis

SPAR Model May Predict Mild Interstitial Lung Disease in Systemic Sclerosis

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The SPAR prediction model might be helpful for the risk stratification of mild ILD in patients with SSc in clinical practice.

PAH in Systemic Sclerosis Increases Risk for Early Mortality

PAH in Systemic Sclerosis Increases Risk for Early Mortality

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The majority of deaths in patients with systemic sclerosis-associated pulmonary arterial hypertension occurred within 4 years of diagnosis.

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

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There was no significant difference in efficacy between sildenafil and bosentan initial combination therapy and sildenafil monotherapy in patients with systemic sclerosis-related pulmonary arterial hypertension.

Smoking Not Associated With Systemic Sclerosis-Specific Cutaneous, Pulmonary Manifestations

Smoking Not Associated With Systemic Sclerosis-Specific Cutaneous, Pulmonary Manifestations

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Smoking status in patients with systemic sclerosis was not significantly associated with systemic sclerosis-specific cutaneous or pulmonary changes.

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

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Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

LPA1 Receptor Antagonist SAR100842 Safe, Well Tolerated in Systemic Sclerosis

LPA1 Receptor Antagonist SAR100842 Safe, Well Tolerated in Systemic Sclerosis

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The investigational drug SAR100842 was safe, moderately effective, and well tolerated in patients with early diffuse cutaneous systemic sclerosis.

Expert Insight: Detecting Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

Expert Insight: Detecting Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

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Although pulmonary arterial hypertension occurs in a minority of patients with systemic sclerosis, clinicians must be attentive to it, as it can emerge at any point over the course of the disease.

Independent Predictors of VTE Identified in Systemic Sclerosis

Independent Predictors of VTE Identified in Systemic Sclerosis

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Researchers evaluated the prevalence, risk factors, and effect of venous thromboembolism on survival in systemic sclerosis.

Predicting Skin Score Changes in Early Diffuse Systemic Sclerosis

Predicting Skin Score Changes in Early Diffuse Systemic Sclerosis

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Two predictive models for progressive skin thickening in patients with early diffuse cutaneous systemic sclerosis were developed to use in clinical practice and to improve recruitment in clinical trials.

Stem Cell Transplant May Benefit Patients With Systemic Sclerosis

Stem Cell Transplant May Benefit Patients With Systemic Sclerosis

Patients who underwent autologous hematopoietic stem cell transplant for systemic sclerosis saw improvements in quality of life.

PAH Incidence in Systemic Sclerosis: Does Algorithm Use Affect Reported Incidence?

PAH Incidence in Systemic Sclerosis: Does Algorithm Use Affect Reported Incidence?

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Use of the DETECT algorithm did not change incidence of PAH, but led to an increased frequency of cases of borderline pulmonary hypertension.

Patients With Early SSc-PAH Development Have Substantial Rate of Disease Progression

Patients With Early SSc-PAH Development Have Substantial Rate of Disease Progression

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Patients with systemic sclerosis and early-diagnosed pulmonary arterial hypertension had disease progression over a relatively short period of time.

Predicting Mortality in Systemic Sclerosis-PAH With CT Signs of Veno-Occlusive Disease

Predicting Mortality in Systemic Sclerosis-PAH With CT Signs of Veno-Occlusive Disease

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A blinded analysis sought to determine whether CT signs of pulmonary veno-occlusive disease are common and predictive of mortality in patients with systemic sclerosis and pulmonary arterial hypertension.

Key Hemodynamic Differences Noted With Scleroderma-Associated PAH vs Idiopathic PAH

Key Hemodynamic Differences Noted With Scleroderma-Associated PAH vs Idiopathic PAH

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Patients with systemic sclerosis-associated pulmonary arterial hypertension display important differences in hemodynamic and pulmonary function parameters compared with patients with idiopathic PAH.

Non-Adjuvanted Influenza A H1N1 Vaccine Safe, Efficacious in Patients With Systemic Sclerosis

Non-Adjuvanted Influenza A H1N1 Vaccine Safe, Efficacious in Patients With Systemic Sclerosis

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Use of the non-adjuvanted influenza A H1N1 vaccine was shown to be safe and efficacious in patients with systemic sclerosis.

Rheumatoid Arthritis, Systemic Sclerosis Patients Should Have Hand Function Evaluated

Rheumatoid Arthritis, Systemic Sclerosis Patients Should Have Hand Function Evaluated

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Study evaluated hand function and potential influence of functional loss on patients' overall physical functions, health-related quality of life, and psychological status in patients with rheumatoid arthritis and systemic sclerosis.

Systematic Sclerosis Ulcers Benefit from Hyperbaric Oxygen Treatment

Systematic Sclerosis Ulcers Benefit from Hyperbaric Oxygen Treatment

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Hyperbaric oxygen therapy completely healed 4 patient's systemic sclerosis ulcers.

Systemic Sclerosis Linked to Occupational Heavy Metal Exposure

Systemic Sclerosis Linked to Occupational Heavy Metal Exposure

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Median levels of 24 elements were assessed in patients with systemic sclerosis and matched controls.

The Handoff: Your Week in Rheumatology News - 2/24/17

The Handoff: Your Week in Rheumatology News - 2/24/17

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Juvenile idiopathic arthritis highlights this week's edition, plus other news in the world of rheumatic disease.

Immunosuppressants Effective for Early Diffuse Cutaneous Systemic Sclerosis Treatment

Immunosuppressants Effective for Early Diffuse Cutaneous Systemic Sclerosis Treatment

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Prospective, observational study assessed 4 treatment protocols and their effects on skin thickening.

Efficacy of Open-Label Tocilizumab in Early Systemic Sclerosis

Efficacy of Open-Label Tocilizumab in Early Systemic Sclerosis

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Dinesh Khanna, MD, MSc, discusses results of the open-label portion of a trial evaluating the safety and efficacy of placebo-treated patients with systemic sclerosis who were switched to received open-label tocilizumab.

Should the Walk Test Be Used as a Surrogate Marker for CV Hemodynamics in SSc-PAH?

Should the Walk Test Be Used as a Surrogate Marker for CV Hemodynamics in SSc-PAH?

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The 6MWD may not accurately serve as a surrogate indicator of treatment outcomes, and that changes in cardiac hemodynamics in response to treatment in patients with SSc-PAH may not be reliably gauged from the 6MWD.

Predictors of Gangrene in Patients With SSc and Digital Ulcers

Predictors of Gangrene in Patients With SSc and Digital Ulcers

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Researchers sought to clarify the rates and risk factors of gangrene formation in patients with SSc utilizing the Digital Ulcer Outcomes Registry.

Decreasing Morbidity Associated With Scleroderma By Addressing Pain Management

Decreasing Morbidity Associated With Scleroderma By Addressing Pain Management

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As part of Scleroderma Awareness Month, physicians specializing in the management of scleroderma discuss mitigating effects of scleroderma-related pain and improving quality of life for their patients.

Ischemic Digital Ulcers Not Reduced by Endothelin-1 Blocker Macitentan in SSc

Ischemic Digital Ulcers Not Reduced by Endothelin-1 Blocker Macitentan in SSc

Treatment with the endothelin-1 blocker macitentan did not reduce the incidence of new digital ulcers over 16 weeks.

Role of Nailfold Videocapillaroscopy, VEGF in the Prognostic Evaluation of SSc

Role of Nailfold Videocapillaroscopy, VEGF in the Prognostic Evaluation of SSc

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Data from this study supports nailfold videocappillaroscopy as a clinically useful tool in the longitudinal evaluation of systemic sclerosis

Predictors of Skin Fibrosis Regression in Diffuse Cutaneous Systemic Sclerosis

Predictors of Skin Fibrosis Regression in Diffuse Cutaneous Systemic Sclerosis

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Regression of skin fibrosis is a feature of the natural history of dcSSc. However, the pattern of regression can be quite heterogeneous despite improvements in predicting progression.

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