There was no significant difference in efficacy between sildenafil and bosentan initial combination therapy and sildenafil monotherapy in patients with systemic sclerosis-related pulmonary arterial hypertension.
Smoking status in patients with systemic sclerosis was not significantly associated with systemic sclerosis-specific cutaneous or pulmonary changes.
Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.
The investigational drug SAR100842 was safe, moderately effective, and well tolerated in patients with early diffuse cutaneous systemic sclerosis.
Although pulmonary arterial hypertension occurs in a minority of patients with systemic sclerosis, clinicians must be attentive to it, as it can emerge at any point over the course of the disease.
Researchers evaluated the prevalence, risk factors, and effect of venous thromboembolism on survival in systemic sclerosis.
Two predictive models for progressive skin thickening in patients with early diffuse cutaneous systemic sclerosis were developed to use in clinical practice and to improve recruitment in clinical trials.
Patients who underwent autologous hematopoietic stem cell transplant for systemic sclerosis saw improvements in quality of life.
Use of the DETECT algorithm did not change incidence of PAH, but led to an increased frequency of cases of borderline pulmonary hypertension.
Patients with systemic sclerosis and early-diagnosed pulmonary arterial hypertension had disease progression over a relatively short period of time.
A blinded analysis sought to determine whether CT signs of pulmonary veno-occlusive disease are common and predictive of mortality in patients with systemic sclerosis and pulmonary arterial hypertension.
Patients with systemic sclerosis-associated pulmonary arterial hypertension display important differences in hemodynamic and pulmonary function parameters compared with patients with idiopathic PAH.
Use of the non-adjuvanted influenza A H1N1 vaccine was shown to be safe and efficacious in patients with systemic sclerosis.
Study evaluated hand function and potential influence of functional loss on patients' overall physical functions, health-related quality of life, and psychological status in patients with rheumatoid arthritis and systemic sclerosis.
Hyperbaric oxygen therapy completely healed 4 patient's systemic sclerosis ulcers.
Median levels of 24 elements were assessed in patients with systemic sclerosis and matched controls.
Juvenile idiopathic arthritis highlights this week's edition, plus other news in the world of rheumatic disease.
Prospective, observational study assessed 4 treatment protocols and their effects on skin thickening.
Dinesh Khanna, MD, MSc, discusses results of the open-label portion of a trial evaluating the safety and efficacy of placebo-treated patients with systemic sclerosis who were switched to received open-label tocilizumab.
The 6MWD may not accurately serve as a surrogate indicator of treatment outcomes, and that changes in cardiac hemodynamics in response to treatment in patients with SSc-PAH may not be reliably gauged from the 6MWD.
Researchers sought to clarify the rates and risk factors of gangrene formation in patients with SSc utilizing the Digital Ulcer Outcomes Registry.
As part of Scleroderma Awareness Month, physicians specializing in the management of scleroderma discuss mitigating effects of scleroderma-related pain and improving quality of life for their patients.
Treatment with the endothelin-1 blocker macitentan did not reduce the incidence of new digital ulcers over 16 weeks.
Data from this study supports nailfold videocappillaroscopy as a clinically useful tool in the longitudinal evaluation of systemic sclerosis
Regression of skin fibrosis is a feature of the natural history of dcSSc. However, the pattern of regression can be quite heterogeneous despite improvements in predicting progression.
Intial therapy with an endothelin receptor antagonist resulted in increased clinical worsening compared to initial treatment with PDE5 inhibitor.
Hemodynamic data and survival were compared in a subgroup of patients with pulmonary arterial hypertension in the setting of connective tissue disease.
CTD is associated with higher prevalence of atherosclerotic cardiovascular disease in African Americans and in young adults.
Engage in this case study to test your diagnostic ability to differentiate pulmonary hypertension in the setting of systemic sclerosis.
Patients with systemic sclerosis may have an increased risk of VTE in the first year following diagnosis.
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