Antiphospholipid Syndrome Archives - Rheumatology Advisor

DAPT Effective, Safe for Prophylaxis of Arterial Thrombosis in Antiphospholipid Syndrome

By

Emily Pond

January 4, 2019

Dual antiplatelet therapy may be effective for the prophylaxis of recurrent arterial thrombosis in patients with antiphospholipid syndrome.

Pregnant woman having sonogram, ultrasound

Systemic Lupus Erythematosus

Intrauterine Fetal Death Associated With Antiphospholipid Syndrome

By

Emily Pond

November 27, 2018

Intrauterine fetal death may be an early sign of antiphospholipid syndrome in pregnant women.

Systemic Lupus Erythematosus

The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome

By

Helen Fosam, PhD

October 31, 2018

Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut.

Systemic Lupus Erythematosus

Promising Antibody Markers Identified for aPL-Related Pregnancy Complications

By

Sheila Jacobs

August 8, 2018

The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, such as intrauterine grown restriction and preeclampsia.

Ischemic stroke is the most common severe neurologic complication of APS. Among 1000 people with APS participating in the Euro-Phospholipid Project, 20% presented with stroke and 11% presented with transient ischemic stroke.2,5 About 13% of patients with stroke are aPL-positive,2 and they are more likely to be younger or female compared with aPL-negative patients.3 More than 20% of strokes in patients <45 years may be related to APS.3 In APS, stroke occurs when a clot forms in an arterial vessel of the brain or when clot or plaque debris travels from another site (usually the heart) to a blood vessel in the brain.2,3 Less common cerebrovascular diseases seen in patients with APS that may increase stroke risk are cerebral venous thrombosis, reversible cerebral vasoconstriction syndrome, acute ischemic encephalopathy (a rare feature of SLE), and Sneddon syndrome.3 To reduce stroke risk, clinicians may want to discuss modifiable risk factors for vascular disease, such as smoking and obesity, with those who are positive for aPL.3 Image Credit: Zephyr/Science Source

Systemic Lupus Erythematosus

Examining the Spectrum of Neurologic Manifestations in Antiphospholipid Syndrome

July 30, 2018

Many patients with antiphospholipid syndrome develop neurological disorders that appear to have a nonthrombotic pathogenesis.

Systemic Lupus Erythematosus

Lupus Family Planning Recommendations Issued by EULAR

By

Crystal Wong, MD

March 6, 2017

A European League Against Rheumatism writing committee has issued recommendations for family planning for women with systemic lupus erythematosus and antiphospholipid syndrome based on a systemic review.

Systemic Lupus Erythematosus

In Vitro Fertilization is Safe and Effective in SLE and APS

By

Crystal Wong, MD

February 6, 2017

Study evaluated the complications and success rates for IVF in women with systemic lupus erythematosus or antiphospholipid syndrome.

Systemic Lupus Erythematosus

EULAR Updates Recommendations for Reproductive Planning in SLE

By

Tori Rodriguez, MA, LPC

September 6, 2016

Multidisciplinary experts provide 12 recommendations for the planning and management of pregnancy in systemic lupus erythematosus and/or antiphospholipid syndrome.

Systemic Lupus Erythematosus

Is There Evidence to Support Serial aPL Testing in Pregnant Women?

By

Corinna Sison, MD

August 5, 2016

Although levels of aPL decreased throughout pregnancy, these changes were not found to be associated with changes in adverse pregnancy outcomes.

General Rheumatology

Persistent LAC Positivity Associated With Higher Vascular Damage Scores in AAV

By

Corinna Sison, MD

May 10, 2016

Persistent lupus anticoagulant positivity in patients with antineutrophil cytoplasmic antibody-associated vasculitis is associated with higher Vasculitis Damage Index scores.