Bone Health Archives

Unnecessary Radiotherapy Given Near End-of-Life in Metastatic Cancer

January 24, 2022

Among patients with bone and brain metastases who died within 90 days of radiotherapy receipt, 21.6 percent received guideline-nonconcordant therapy.

General Rheumatology

Cholecalciferol Beneficial for Bone Loss in Kidney Transplant Recipients

By

Colby Stong

January 19, 2022

The effect of cholecalciferol supplementation on parathyroid hormone levels and bone loss at the lumbar spine in kidney transplant recipients was studied in a placebo-controlled trial.

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Osteoporosis

Bisphosphonates Reduce Incidence of Hip Fractures in Patients With Osteoporosis, Osteopenia

By

Jessica Nye, PhD

January 13, 2022

Researchers investigated whether hip fractures could be prevented with bisphosphonates in people with osteoporosis or osteopenia.

Osteoporosis

Mind-Body Exercise Improves Bone Mineral Density in Lumbar Spine and Femoral Neck

By

Colby Stong

January 10, 2022

Exercise slows bone loss and increases bone density in people at risk for osteoporosis, but which exercises are most effective are unclear. Investigators sought the answer.

Osteoarthritis

Reduced Bone Microarchitecture, Lower BMD Observed Among Patients With Peripheral Hypertrophic Osteoarthropathy

By

Rebecca Chu, PharmD, RPh

January 6, 2022

Researchers evaluated the bone microarchitecture and strength in patients with primary hypertrophic osteoarthropathy using HR-pQCT.

Osteoporosis

Bone Density Loss Similar Among Postmenopausal Black and White Women

By

Colby Stong

December 29, 2021

Age and menopause may contribute to bone fracture risk in women, but the rate may vary by race and ethnicity. Researchers studied changes in bone mineral density in Black and White women to discover if race had an impact on bone loss.

Osteoporosis

Romosozumab Superior to Teriparatide in Improving Bone Mineral Density in Postmenopausal Women

By

Dhivya Haridass, PhD

December 13, 2021

Researchers compared the efficacy of romosozumab vs teriparatide in improving vertebral bone structure in women with low bone density.

Osteoporosis

Oral Health in Older Adults Linked to Bone Density Measurements

By

Jessica Nye, PhD

December 2, 2021

Bone density often decreases with age and is closely related to overall physical performance. Researchers studied whether the relationship between bone density and overall physical health extended to oral health as well.

Patients with RA experience localized and generalized bone loss.2 Data have also shown that patients with well-controlled RA have significantly more bone loss than healthy individuals.4 The pathology of bone loss in RA is multifactorial and complex. The pannus, a proliferation of inflamed synovial tissue, releases several proinflammatory cytokines. Some, such as TNF-α, IL-1, IL-6, and IL-17, are osteoclastogenic and promote bone resorption, partly through upregulation of nuclear factor-kB ligand.1,3,5 They also inhibit anti-osteoclastogenic cytokines.1 Further, TNF-α upregulates proteins that inhibit the Wnt pathway, thus suppressing osteoblast activity.1,3,5 The resulting imbalance in bone remodeling, favoring bone resorption, causes bone loss and inferior bone quality. Immobility and glucocorticoid use, both common in patients with RA, also promote bone loss.1,2 Standard risk factors for bone loss may exacerbate RA-induced bone loss.5

News, Osteoporosis

Long-Term Bone Loss Studied in Postmenopausal Women

October 28, 2021

Postmenopausal bone loss averaged about 10 percent during 25 years of follow-up in a random sample of women.

General Rheumatology

Link Between Vascular Pathophysiology and Bone Metabolism Studied in Patients With Arthritis

By

Bradley van Paridon

October 26, 2021

Researchers determined the correlation between vascular pathophysiology and bone metabolism in patients with rheumatoid arthritis and ankylosing spondylitis.