Bone Health Archives - Rheumatology Advisor

$In patients with HIV, the disease process and ART may contribute to bone loss, resulting in osteopenia or osteoporosis and increased fracture risk.3,10 Proinflammatory cytokines and viral load contribute directly to reduced bone mineral density through their effects on osteoclast and osteoblast activity, inhibiting new bone formation and accelerating bone loss.3 Other risk factors for bone loss or fracture in the HIV population include low body mass index, smoking, substance abuse, glucocorticoid therapy, hypogonadism, coinfection with hepatitis B virus or hepatitis C virus, and vitamin D deficiency (affects ~90% of patients).3,11 Bone loss caused by ART emerges within 1 to 2 years after starting therapy.3,11 Tenofovir-based regimens are associated with higher rates of bone loss.3,11 Guidelines suggest avoiding tenofovir disoproxil fumarate or PI-boosting regimens in patients at high risk.3 Bisphosphonates (eg, alendronate or zoledronate) are recommended for those with HIV who have osteoporosis.3$

General Rheumatology

Obstructive Sleep Apnea Tied to Worse Bone Health

September 23, 2020

History of obstructive sleep apnea (OSA) is independently associated with a higher risk for confirmed vertebral fracture.

ASBMR 2020

Type 2 Diabetes Has Detrimental Effects on Trabecular Bone Quality in Osteoporosis

By

Amit Akirov, MD

September 11, 2020

Researchers evaluated and compared trabecular bone quality in patients with osteoporosis with and without type 2 diabetes.

Osteoporosis

Teriparatide for Severe Osteoporosis Stabilizes Bone Health in Patients With Duchenne Muscular Dystrophy

By

Morgan E. Meissner

August 6, 2020

Researchers evaluated the safety and efficacy of teriparatide for the treatment of severe osteoporosis in patients with Duchenne muscular dystrophy.

Osteoporosis

Exposures During Gestation and Infancy May Affect Young Adult Bone Health

July 20, 2020

Factors during gestation and infancy may impact bone health in young adulthood.

Osteoporosis

Evaluating Bone Microarchitecture and Strength in Women With HIV

By

Amit Akirov, MD

July 16, 2020

Bone microarchitecture and strength are reduced in women living with HIV, and tenofovir treatment may contribute to bone deficits.

Osteoporosis

Increased Risk for Fracture Among Patients With Neuromyelitis Optica

By

Amit Akirov, MD

May 28, 2020

Given the limited data is available on bone health of patients with NMOSD-AQP4, researchers aimed to investigate their risk for fracture and bone loss.

$In patients with HIV, the disease process and ART may contribute to bone loss, resulting in osteopenia or osteoporosis and increased fracture risk.3,10 Proinflammatory cytokines and viral load contribute directly to reduced bone mineral density through their effects on osteoclast and osteoblast activity, inhibiting new bone formation and accelerating bone loss.3 Other risk factors for bone loss or fracture in the HIV population include low body mass index, smoking, substance abuse, glucocorticoid therapy, hypogonadism, coinfection with hepatitis B virus or hepatitis C virus, and vitamin D deficiency (affects ~90% of patients).3,11 Bone loss caused by ART emerges within 1 to 2 years after starting therapy.3,11 Tenofovir-based regimens are associated with higher rates of bone loss.3,11 Guidelines suggest avoiding tenofovir disoproxil fumarate or PI-boosting regimens in patients at high risk.3 Bisphosphonates (eg, alendronate or zoledronate) are recommended for those with HIV who have osteoporosis.3$

Osteoporosis

Bone Health Declining in Adults With and Without Prediabetes in the United States

May 19, 2020

The bone health of adults older than 40 years of age is declining for individuals both with normal glucose regulation and prediabetes.

$child with long bone fracture, leg fracture, pediatrics$

Pediatric Rheumatology

Racial Differences Seen in Pain Management for Children With Long Bone Fractures

May 1, 2020

There are racial differences in pain management and pain outcomes for children seen in the emergency department for long-bone fractures.

Pediatric Rheumatology

Children With HIV Receiving ART May Have Deficits in Bone Architecture and Strength

By

Zahra Masoud

April 30, 2020

Children living with HIV demonstrate deficits in bone architecture and reductions in bone strength, compared with children without HIV.

Osteoporosis

LDL-C Lowering Effect of Statins Partly Accounts for Related Improvements in BMD

By

Rheumatology Advisor Contributing Writer

April 14, 2020

The improvements in estimated and total body bone mineral density observed with statin treatment may be partly accounted for by their low-density lipoprotein cholesterol-lowering effect.