Bone Health Archives - Rheumatology Advisor

Researchers determined the association between grip strength and distal radius bone density, size, and strength in both older men and women enrolled in the Framingham Osteoporosis study.

General Rheumatology

Alterations in Bone Structure, Composition May Cause Trabecular Bone Fragility in Type 2 Diabetes

By

Jessica Nye, PhD

March 9, 2021

Patients with type 2 diabetes face up to a three-fold increased risk of hip fracture, despite adequate areal bone mineral density which may underestimate fracture risk in these patients.

Osteoporosis

FSH Levels in Older Postmenopausal Women Affect Bone and Body Composition

By

Brandon May

February 22, 2021

The objective of this study was to investigate the associations between endogenous FSH levels and BMD, BMA, and body composition in older adults, independent of estradiol and testosterone levels.

General Rheumatology

Abnormal Bone Microarchitecture Linked to Complications After Spinal Fusion

February 4, 2021

Abnormalities of trabecular and cortical microarchitecture are associated with skeletal complications in the 6 months following spinal fusion surgery.

Osteoporosis

Denosumab Studied for Prosthesis-Related Osteolysis

January 29, 2021

A single dose of denosumab results in a reduction in osteoclast numbers in patients with osteolysis undergoing total hip arthroplasty surgery.

$In patients with HIV, the disease process and ART may contribute to bone loss, resulting in osteopenia or osteoporosis and increased fracture risk.3,10 Proinflammatory cytokines and viral load contribute directly to reduced bone mineral density through their effects on osteoclast and osteoblast activity, inhibiting new bone formation and accelerating bone loss.3 Other risk factors for bone loss or fracture in the HIV population include low body mass index, smoking, substance abuse, glucocorticoid therapy, hypogonadism, coinfection with hepatitis B virus or hepatitis C virus, and vitamin D deficiency (affects ~90% of patients).3,11 Bone loss caused by ART emerges within 1 to 2 years after starting therapy.3,11 Tenofovir-based regimens are associated with higher rates of bone loss.3,11 Guidelines suggest avoiding tenofovir disoproxil fumarate or PI-boosting regimens in patients at high risk.3 Bisphosphonates (eg, alendronate or zoledronate) are recommended for those with HIV who have osteoporosis.3$

General Rheumatology

Comparing Free and Bioavailable vs Total 25(OH)D to Predict Bone Health

By

Lauren Biscaldi

January 22, 2021

Researchers sought to investigate the impact of vitamin D-specific variables on indices of bone and mineral metabolism in older adults.

Osteoporosis

Jaw Osteonecrosis Linked to Treatment for Bone Metastases

January 15, 2021

The cumulative three-year incidence of osteonecrosis of the jaw is 2.8% in cancer patients receiving zoledronic acid for metastatic bone disease.

Osteoporosis

Corticosteroid Exposure Affects Bone Health in Patients With Asthma

October 27, 2020

For patients with asthma, oral corticosteroid and inhaled corticosteroid use is associated with an increased risk for osteoporosis and fragility fractures