Bone Health Archives

Osteoporosis screening in an older woman.

Romosozumab Superior to Teriparatide in Improving Bone Mineral Density in Postmenopausal Women

By

December 13, 2021

Researchers compared the efficacy of romosozumab vs teriparatide in improving vertebral bone structure in women with low bone density.

Osteoporosis

Oral Health in Older Adults Linked to Bone Density Measurements

By

Jessica Nye, PhD

December 2, 2021

Bone density often decreases with age and is closely related to overall physical performance. Researchers studied whether the relationship between bone density and overall physical health extended to oral health as well.

Patients with RA experience localized and generalized bone loss.2 Data have also shown that patients with well-controlled RA have significantly more bone loss than healthy individuals.4 The pathology of bone loss in RA is multifactorial and complex. The pannus, a proliferation of inflamed synovial tissue, releases several proinflammatory cytokines. Some, such as TNF-α, IL-1, IL-6, and IL-17, are osteoclastogenic and promote bone resorption, partly through upregulation of nuclear factor-kB ligand.1,3,5 They also inhibit anti-osteoclastogenic cytokines.1 Further, TNF-α upregulates proteins that inhibit the Wnt pathway, thus suppressing osteoblast activity.1,3,5 The resulting imbalance in bone remodeling, favoring bone resorption, causes bone loss and inferior bone quality. Immobility and glucocorticoid use, both common in patients with RA, also promote bone loss.1,2 Standard risk factors for bone loss may exacerbate RA-induced bone loss.5

News, Osteoporosis

Long-Term Bone Loss Studied in Postmenopausal Women

October 28, 2021

Postmenopausal bone loss averaged about 10 percent during 25 years of follow-up in a random sample of women.

General Rheumatology

Link Between Vascular Pathophysiology and Bone Metabolism Studied in Patients With Arthritis

By

Bradley van Paridon

October 26, 2021

Researchers determined the correlation between vascular pathophysiology and bone metabolism in patients with rheumatoid arthritis and ankylosing spondylitis.

Female patient in hospital bed looking at xray with clincian

Osteoporosis

Acute-Phase Reaction to Zoledronic Acid and Bone Fracture Risk Reduction

By

Colby Stong

October 26, 2021

Zoledronic acid, an annual intravenous therapy for osteoporosis, sometimes causes acute-phase reactions such as fever, myalgia, and flu-like symptoms after infusion. Researchers wondered if these initial transient reactions could be used as a predictor of the drug’s efficacy in people at risk for fractures.

General Rheumatology

Longitudinal Study Evaluates BMD Among Adults With Pediatric Differentiated Thyroid Carcinoma

By

Lauren Biscaldi

October 20, 2021

Investigators studied the bones of adults who had thyroid cancer as children to find out if treatment for the disease carried consequences into adulthood.

Rheumatoid Arthritis

Denosumab Discontinuation Results in Reversal of Its Effects on BMD in Patients With RA

By

Bradley van Paridon

October 19, 2021

Researchers assessed changes in bone turnover and bone mineral density in patients with rheumatoid arthritis receiving treatment with glucocorticoids after discontinuing denosumab for 12 months.

ASBMR 2021

Teriparatide Improves Bone Quality Indices in Postmenopausal Osteoporosis to Premenopausal Levels

By

Inga Back, MPH

October 15, 2021

Researchers assessed the effect of treatment with teriparatide on bone quality indices at trabecular surfaces in patients with postmenopausal osteoporosis.