Bone Health Archives

scanning electron migrograph (SEM) of osteoporosis

Microstructural Bone Changes Linked to Autoimmunity and RA Onset

By

Rheumatology Advisor Contributing Writer

April 3, 2020

Microstructural changes of the periarticular cortical bone represent a link between symptomatic autoimmunity and rheumatoid arthritis.

$In patients with HIV, the disease process and ART may contribute to bone loss, resulting in osteopenia or osteoporosis and increased fracture risk.3,10 Proinflammatory cytokines and viral load contribute directly to reduced bone mineral density through their effects on osteoclast and osteoblast activity, inhibiting new bone formation and accelerating bone loss.3 Other risk factors for bone loss or fracture in the HIV population include low body mass index, smoking, substance abuse, glucocorticoid therapy, hypogonadism, coinfection with hepatitis B virus or hepatitis C virus, and vitamin D deficiency (affects ~90% of patients).3,11 Bone loss caused by ART emerges within 1 to 2 years after starting therapy.3,11 Tenofovir-based regimens are associated with higher rates of bone loss.3,11 Guidelines suggest avoiding tenofovir disoproxil fumarate or PI-boosting regimens in patients at high risk.3 Bisphosphonates (eg, alendronate or zoledronate) are recommended for those with HIV who have osteoporosis.3$

Osteoporosis

Antiretroviral Therapy May Reduce Bone Mineral Density in Adolescents and Elderly With HIV

By

Zahra Masoud

April 2, 2020

Particular antiretroviral therapy (ART) regimens may decrease bone mass density (BMD) in both adolescents and older people living with HIV (PWHIV).

Osteoporosis

Bone-Targeted Exercise Strategies to Reduce Fracture Risk in Men

By

Amit Akirov, MD

March 30, 2020

High-intensity progressive resistance and impact training is a well-tolerated program that may improve bone mineral density and physical function in older men.

Osteoporosis

Evaluating Weekly Teriparatide vs Bisphosphonate Therapy After Lumbar Fusion in Patients With Osteoporosis

By

Morgan E. Meissner

February 28, 2020

Recovery after multilevel lumbar interbody fusion is similar between patients who receive weekly teriparatide and bisphosphonate therapy.

Osteoporosis

Infrequent Dosing of Zoledronate May Prevent Bone Loss in Postmenopausal Women

By

Amit Akirov, MD

February 27, 2020

In postmenopausal women with osteoporosis, 2 doses of zoledronate 5 mg at an approximately 6-year interval prevented bone loss for almost 11 years.

Osteoporosis

Endocrine Society Updates Postmenopausal Osteoporosis Management Guidelines to Include Romosozumab

By

Rachael Beairsto

February 20, 2020

The Endocrine Society has issued an update to the organization’s 2019 clinical practice guideline on pharmacologic management of osteoporosis to include romosozumab.

Osteoporosis

Vitamin D Supplementation Alone Does Not Increase Bone Structure, Strength

By

Morgan E. Meissner

February 4, 2020

In older adults, no significant changes in bone strength or structure were noted after 2 years of daily vitamin D supplementation.

Osteoporosis

Ambient Air Pollution Linked to Lower Bone Mineral Content

January 13, 2020

Exposure to ambient particulate matter air pollution with an aerodynamic diameter <2.5 µm (PM2.5) and black carbon (BC) is associated with lower bone mineral content (BMC) in adults.

General Rheumatology

Serum Calcium May Have Negative Effect on Bone Mineral Density

By

Amit Akirov, MD

November 13, 2019

Elevated calcium levels may lead to suboptimal growth of bone, according to the study’s findings.

Osteoporosis

Recommendations for Secondary Fracture Prevention in Elderly Patients

By

Amit Akirov, MD

October 15, 2019

The American Society for Bone and Mineral Research developed 13 clinical recommendations (7 primary and 6 secondary) to address the undertreatment of osteoporosis-related fractures and prevent secondary fracture among persons aged ≥65 years with hip or vertebral fractures.