Cardiovascular Disease

Treatment With DMARDs Improves Cardiovascular Abnormalities in Early Rheumatoid Arthritis

Alyssa Capel

October 13, 2020

Researchers determined the effect of disease-modifying antirheumatic drug therapy on patients with early rheumatoid arthritis with cardiovascular disease.

Gout

Gout May Not Be Associated With Cardiovascular Complications in Peripheral Artery Disease

Jessica Nye, PhD

October 5, 2020

Gout was not found to be associated with increased risk for cardiovascular complications in patients with peripheral artery disease.

Uncategorized

Thromboembolic Disorders: Treatments

April 29, 2020

Anticoagulants, antiplatelets, and thrombolytics for the treatment and/or prophylaxis of venous and arterial thrombosis.

General Rheumatology

Aspirin May Be Considered for Primary Prevention of Cardiovascular Disease in Rheumatic Diseases

Amit Akirov, MD

September 23, 2020

Study authors reviewed the evidence on the effectiveness of low-dose aspirin in the primary prevention of cardiovascular disease in systemic autoimmune rheumatic diseases.

Spondyloarthritis

Disease Activity Tool, Carotid Plaque Predicts Cardiovascular Events in Patients with Psoriatic Arthritis

Amit Akirov, MD

August 25, 2020

Researchers examined whether a disease activity tool and the presence of carotid plaques can predict cardiovascular events, independent of traditional risk factors, in psoriatic arthritis.

Osteoporosis

Inhibition of Sclerostin With Romosozumab May Increase Cardiovascular Risk

June 30, 2020

Inhibition of sclerostin with romosozumab may increase cardiovascular risk.

Rheumatoid Arthritis

Carotid Plaques Predict Cardiovascular Events and Mortality in Patients With Rheumatoid Arthritis

Emily Pond

June 17, 2020

Researchers identified carotid plaques as predictors of cardiovascular events in patients with rheumatoid arthritis.

Gout

Allopurinol Not Associated With Increased All-Cause Mortality in Gout

Emily Pond

May 27, 2020

Researchers evaluated the association between allopurinol use and mortality in patients with gout.

Pediatric Rheumatology

Immune Globulin Therapy Linked to Heart Function Recovery in COVID-Related Multisystem Inflammatory Syndrome

Cassandra Pardini, PharmD

May 26, 2020

The use of immune globulin therapy appears to benefit children who experience acute heart failure caused by coronavirus disease 2019 (COVID-19)-related multisystem inflammatory syndrome, according to the findings of a case series recently published in Circulation.

Osteoporosis

Osteoporotic Fracture Risk Lower With Direct Oral Anticoagulants vs Warfarin in Atrial Fibrillation

May 20, 2020

The risk for osteoporotic fracture appears to be lower with DOAC use compared with warfarin use in atrial fibrillation.

Next post in Osteoporosis

$In patients with HIV, the disease process and ART may contribute to bone loss, resulting in osteopenia or osteoporosis and increased fracture risk.3,10 Proinflammatory cytokines and viral load contribute directly to reduced bone mineral density through their effects on osteoclast and osteoblast activity, inhibiting new bone formation and accelerating bone loss.3 Other risk factors for bone loss or fracture in the HIV population include low body mass index, smoking, substance abuse, glucocorticoid therapy, hypogonadism, coinfection with hepatitis B virus or hepatitis C virus, and vitamin D deficiency (affects ~90% of patients).3,11 Bone loss caused by ART emerges within 1 to 2 years after starting therapy.3,11 Tenofovir-based regimens are associated with higher rates of bone loss.3,11 Guidelines suggest avoiding tenofovir disoproxil fumarate or PI-boosting regimens in patients at high risk.3 Bisphosphonates (eg, alendronate or zoledronate) are recommended for those with HIV who have osteoporosis.3$