SLE: Imbalance in Autoregulation and Feedback Affects B-Cell Lineage Differentiation
An imbalance in this auto-regulatory feedback loop may play a role in the pathogenesis of SLE, and could be a mechanism for pharmacotherapeutic intervention.
Systemic Lupus Erythematosus
Case Study and Clinical Highlight: Headache, Confusion, and Seizures in a Patient With SLE
Since certain syndromes are associated with good prognosis in a majority of patients with systemic lupus erythematosus, prompt diagnosis and initiation of early goal-directed treatment is crucial.
SLE Associated With Elevated Risk for Atherosclerosis
Atherosclerosis was found to be prevalent among Danish patients with lupus without prior cardiovascular disease. Research demonstrated that atherosclerosis screening focused on one vascular territory is insufficient to make a diagnosis.
Analysis of Incidence Rates of ESRD in Newly Diagnosed SLE
An estimate of the incidence rate of end-stage renal disease was identified in a population of patients with newly diagnosed SLE in the Atlanta, Georgia metropolitan area.
Unbalanced B-cell Receptor Signaling Promotes B-cell Survival in SLE
An imbalance between serine and tyrosine phosphatases contributes to a dysregulation of B-cell receptor signaling in patients with SLE.
Improvements in Muscle Strength May Reduce Disability in SLE
A study was conducted examining the correlation between muscle strength, muscle mass, and physical disability in adult women with SLE. The researchers found that muscle strength was inversely related to physical disability in SLE.
Incidence of ASCVD Increased in African Americans and Young Adults With Inflammatory CTD
CTD is associated with higher prevalence of atherosclerotic cardiovascular disease in African Americans and in young adults.
Cigarette Smoke Exposure Linked to Increased Morbidity in SLE
Cigarette smoke exposure is associated with increased morbidity in SLE as assessed by SDI score.
Cutaneous Manifestations of SLE Less Prevalent in Late-onset Patient Subgroup
A meta-analysis showed that cutaneous manifestations of SLE are less common in patients with late-onset SLE.
Lupus Anticoagulant is Main Predictor of Poor Pregnancy Outcomes in SLE
Pregnancy in women with SLE carries a higher maternal and fetal risk compared with pregnancy in healthy women. The presence of LAC appears to be most predictive of poor pregnancy outcomes.
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