RHEUM YIR RA 2019

IL-1 Inhibition as Targeted Treatment for RA, T2D

Researchers investigated the role of interleukin-1 inhibition in improving glycemic and inflammatory parameters in patients with rheumatoid arthritis and type 2 diabetes.

RA Risk Linked With Previous Antibiotic Exposure

Researchers assessed the risk for rheumatoid arthritis in patients receiving antibiotics.

HLA Alleles With Risk for AS, RA Affect Gut Microbiome

Researchers examined the effects of HLA-B27 and HLA-DRB1 alleles on the intestinal microbiome of healthy individuals.

Upadacitinib Approved for Moderate to Severe RA

The Food and Drug Administration (FDA) has approved Rinvoq (upadacitinib), a Janus kinase (JAK) inhibitor, for the treatment of adults with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to methotrexate.

Machine Learning Model Can Predict Anti-TNF Drug Response in RA

The model improves anti-TNF drug selection and the effect of genetic markers across multiple cohorts.

Neutrophil-Lymphocyte Ratio May Be Used as Disease Activity Marker in RA

This is the first study to examine the real-world outcome of the management of RA using neutrophil-lymphocyte ratio.

Q&A: Bioelectronic Implant Could Benefit Patients With RA

Results of an investigational US pilot study have shown that a proprietary bioelectronic microregulator device, manufactured by SetPoint Medical, can benefit patients with rheumatoid arthritis.

Efficacy of Upadacitinib Monotherapy for Active RA With Inadequate MTX Response

Upadacitinib monotherapy resulted in improvements in clinical and functional outcomes vs continuing methotrexate in a population of methotrexate inadequate-responders with active RA.

Efficacy of Filgotinib in Methotrexate-Naive Patients With RA

Study compared efficacy and safety of filgotinib with and without methotrexate in patients with rheumatoid arthritis who were naive to methotrexate therapy.

MTX Not Associated With Increased Interstitial Lung Disease Risk in RA

Researchers sought to determine whether exposure to methotrexate for rheumatoid arthritis may lead to interstitial lung disease.

Gradual TNFi vs csDMARD Tapering in Rheumatoid Arthritis

Researchers evaluated the effectiveness of 2 tapering strategies in patients with RA who had achieved controlled disease activity.

Discrete Trajectories of Persistent Pain Identified in Rheumatoid Arthritis

In patients with rheumatoid arthritis treated with anti-inflammatory medications, long-term persistent pain was found to be common and may be predicted by higher levels of disability and a history of smoking.

Fish Intake Does May Not Protect Against RA

Dietary intake of fish did not have a protective effect against rheumatoid arthritis.

Tender Joint Count May Not Reflect Inflammation in RA

The inclusion of tender joint count in the Composite Disease Activity Score may contribute to misleading information about inflammatory activity.

Increased Risk for Cancer Observed in Abatacept-Treated Rheumatoid Arthritis

The use of abatacept as an initial bDMARD for the treatment of patients with rheumatoid arthritis is associated with a slightly elevated risk for cancer overall.